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A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation.
Ralvenius, William T; Mungenast, Alison E; Woolf, Hannah; Huston, Margaret M; Gillingham, Tyler Z; Godin, Stephen K; Penney, Jay; Cam, Hugh P; Gao, Fan; Fernandez, Celia G; Czako, Barbara; Lightfoot, Yaima; Ray, William J; Beckmann, Adrian; Goate, Alison M; Marcora, Edoardo; Romero-Molina, Carmen; Ayata, Pinar; Schaefer, Anne; Gjoneska, Elizabeta; Tsai, Li-Huei.
Affiliation
  • Ralvenius WT; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Mungenast AE; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Woolf H; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Huston MM; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Gillingham TZ; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Godin SK; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Penney J; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Cam HP; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Gao F; Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Fernandez CG; The Neurodegeneration Consortium, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Czako B; The Neurodegeneration Consortium, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Lightfoot Y; The Neurodegeneration Consortium, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Ray WJ; The Neurodegeneration Consortium, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Beckmann A; The Neurodegeneration Consortium, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • Goate AM; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Marcora E; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai , New York, NY, USA.
  • Romero-Molina C; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Ayata P; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Schaefer A; Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai , New York, NY, USA.
  • Gjoneska E; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Tsai LH; Nash Family Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
J Exp Med ; 220(11)2023 11 06.
Article in En | MEDLINE | ID: mdl-37642942
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alzheimer Disease / Neuroinflammatory Diseases Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Exp Med Year: 2023 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alzheimer Disease / Neuroinflammatory Diseases Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Exp Med Year: 2023 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos