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An engineered bispecific nanobody in tetrameric secretory IgA format confers broad neutralization against SARS-CoV-1&2 and most variants.
Zeng, Weihong; Jia, Xiaoying; Chi, Xiangyang; Zhang, Xinghai; Li, Entao; Wu, Yan; Liu, Yang; Han, Jin; Ni, Kang; Ye, Xiaodong; Hu, Xiaowen; Ma, Huan; Yu, Changming; Chiu, Sandra; Jin, Tengchuan.
Affiliation
  • Zeng W; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.
  • Jia X; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430062, China.
  • Chi X; Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China.
  • Zhang X; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430062, China.
  • Li E; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230027, China.
  • Wu Y; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430062, China.
  • Liu Y; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430062, China.
  • Han J; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230027, China.
  • Ni K; Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui 230026, China.
  • Ye X; Department of Chemical Physics, University of Science and Technology of China, Hefei, Anhui 230026, China.
  • Hu X; Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.
  • Ma H; Institute of Clinical Immunology, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, China. Electronic address: mahuan86@ustc.edu.cn.
  • Yu C; Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China. Electronic address: yuchangming@126.com.
  • Chiu S; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address: qiux@ustc.edu.cn.
  • Jin T; Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230027, China; Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei, Anhui, China. Electronic address: jint@ustc.edu.cn.
Int J Biol Macromol ; 253(Pt 3): 126817, 2023 Dec 31.
Article in En | MEDLINE | ID: mdl-37690653
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: SARS-CoV-2 / Antibodies Limits: Animals Language: En Journal: Int J Biol Macromol Year: 2023 Document type: Article Affiliation country: China Country of publication: Países Bajos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: SARS-CoV-2 / Antibodies Limits: Animals Language: En Journal: Int J Biol Macromol Year: 2023 Document type: Article Affiliation country: China Country of publication: Países Bajos