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5-Substituted Uridines with Activity against Gram-Positive Bacteria.
Makarov, Dmitry A; Negrya, Sergey D; Jasko, Maxim V; Karpenko, Inna L; Solyev, Pavel N; Chekhov, Vladimir O; Kaluzhny, Dmitry N; Efremenkova, Olga V; Vasilyeva, Byazilya F; Chizhov, Alexander O; Avdanina, Darya A; Zhgun, Alexander A; Kochetkov, Sergey N; Alexandrova, Liudmila A.
Affiliation
  • Makarov DA; Engelhardt Institute of Molecular Biology RAS, 32 Vavilov str., Moscow, 119991, Russia.
  • Negrya SD; Engelhardt Institute of Molecular Biology RAS, 32 Vavilov str., Moscow, 119991, Russia.
  • Jasko MV; Engelhardt Institute of Molecular Biology RAS, 32 Vavilov str., Moscow, 119991, Russia.
  • Karpenko IL; Engelhardt Institute of Molecular Biology RAS, 32 Vavilov str., Moscow, 119991, Russia.
  • Solyev PN; Engelhardt Institute of Molecular Biology RAS, 32 Vavilov str., Moscow, 119991, Russia.
  • Chekhov VO; Engelhardt Institute of Molecular Biology RAS, 32 Vavilov str., Moscow, 119991, Russia.
  • Kaluzhny DN; Engelhardt Institute of Molecular Biology RAS, 32 Vavilov str., Moscow, 119991, Russia.
  • Efremenkova OV; Gause Institute of New Antibiotics, 11 Bol'shaya Pirogovskaya, Moscow, 119021, Russia.
  • Vasilyeva BF; Gause Institute of New Antibiotics, 11 Bol'shaya Pirogovskaya, Moscow, 119021, Russia.
  • Chizhov AO; Zelinsky Institute of Organic Chemistry RAS, 47 Leninsky Ave., Moscow, 119991, Russia.
  • Avdanina DA; Research Center of Biotechnology RAS, 33 Leninsky Ave., Moscow, 119071, Russia.
  • Zhgun AA; Research Center of Biotechnology RAS, 33 Leninsky Ave., Moscow, 119071, Russia.
  • Kochetkov SN; Engelhardt Institute of Molecular Biology RAS, 32 Vavilov str., Moscow, 119991, Russia.
  • Alexandrova LA; Engelhardt Institute of Molecular Biology RAS, 32 Vavilov str., Moscow, 119991, Russia.
ChemMedChem ; 18(21): e202300366, 2023 11 02.
Article in En | MEDLINE | ID: mdl-37707314
ABSTRACT
The emergence of drug-resistant strains of pathogenic microorganisms necessitates the creation of new drugs. A series of uridine derivatives containing an extended substituent at the C-5 position as well as C-5 alkyloxymethyl, alkylthiomethyl, alkyltriazolylmethyl, alkylsulfinylmethyl and alkylsulfonylmethyl uridines were obtained in order to explore their antimicrobial properties and solubility. It has been shown that new ribonucleoside derivatives have an order of magnitude better solubility in water compared to their 2'-deoxy analogues and effectively inhibit the growth of a number of Gram-positive bacteria, including resistant strains of Mycobacterium smegmatis (MIC=15-200 µg/mL) and Staphylococcus aureus (MIC=25-100 µg/mL). Their activity is comparable to that of some antibiotics used in medicine.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anti-Infective Agents / Anti-Bacterial Agents Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2023 Document type: Article Affiliation country: Rusia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Anti-Infective Agents / Anti-Bacterial Agents Language: En Journal: ChemMedChem Journal subject: FARMACOLOGIA / QUIMICA Year: 2023 Document type: Article Affiliation country: Rusia