IFN-γ promotes PANoptosis in Pasteurella multocida toxin-induced pneumonia in mice.
Vet Microbiol
; 285: 109848, 2023 Oct.
Article
in En
| MEDLINE
| ID: mdl-37722207
ABSTRACT
Interferon-γ (IFN-γ) is a pleiotropic cytokine that regulates diverse biological functions, including modulation of inflammatory response and innate and adaptive immunity. In our study, we found that IFN-γ plays an important role in the regulation of Pasteurella multocida toxin-associated pneumonia. In work described here, we demonstrated that rPMT induced a lethal pneumonia in WT mice and the severity of the pneumonia was substantially alleviated in IFN-γ-deficient mice, IFN-γ deficiency significantly elevated the survival rate and reduced the pathological lesions of the lungs after rPMT challenged. Notably, IFN-γ deficiency significantly decreased myeloperoxidase (MPO) expression abundance in the lung tissue, and the MPO was mainly expressed in the lung tissue injury region of WT mice. More importantly, IFN-γ deficiency impaired the activation of PANoptosis specific markers, including the caspase 3, GSDMD, and MLKL, and reduced the expression of IL-1ß. Cumulatively, this study demonstrates that IFN-γ promotes PANoptosis in PMT induced pneumonia in mice, providing a basis for studying the pathogenic mechanism of PMT.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pasteurella Infections
/
Pneumonia
/
Bacterial Toxins
/
Pasteurella multocida
Limits:
Animals
Language:
En
Journal:
Vet Microbiol
Year:
2023
Document type:
Article
Affiliation country:
China