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Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on transplantation.
Chawda, Mira M; Ross, Susan; Lau, Ching-In; Yánez, Diana C; Rowell, Jasmine; Kilbride, Peter; Crompton, Tessa.
Affiliation
  • Chawda MM; UCL Great Ormond Street Institute of Child Health, London, UK.
  • Ross S; UCL Great Ormond Street Institute of Child Health, London, UK.
  • Lau CI; UCL Great Ormond Street Institute of Child Health, London, UK.
  • Yánez DC; UCL Great Ormond Street Institute of Child Health, London, UK.
  • Rowell J; UCL Great Ormond Street Institute of Child Health, London, UK.
  • Kilbride P; Cytiva, Danaher Corporation, Cambridge, UK.
  • Crompton T; UCL Great Ormond Street Institute of Child Health, London, UK.
Eur J Immunol ; 53(12): e2350546, 2023 12.
Article in En | MEDLINE | ID: mdl-37751619
ABSTRACT
Cryopreservation of mouse thymus depletes donor thymocytes but preserves thymus function when transplanted after thawing into athymic mice. No differences in immune reconstitution were observed between fresh and frozen/thawed transplants suggesting that donor thymocyte depletion does not affect outcome. Thus, cryopreservation of thymus may improve outcomes in thymus transplant patients.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thymocytes / Immune Reconstitution Limits: Animals / Humans Language: En Journal: Eur J Immunol Year: 2023 Document type: Article Affiliation country: Reino Unido
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thymocytes / Immune Reconstitution Limits: Animals / Humans Language: En Journal: Eur J Immunol Year: 2023 Document type: Article Affiliation country: Reino Unido