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Recent advances in proteomic-based diagnostics of cystic fibrosis.
Nimer, Refat M; Abdel Rahman, Anas M.
Affiliation
  • Nimer RM; Department of Medical Laboratory Sciences, Jordan University of Science and Technology, Irbid, Jordan.
  • Abdel Rahman AM; Metabolomics Section, Department of Clinical Genomics, Center for Genome Medicine, King Faisal Specialist Hospital and Research Centre (KFSHRC), Riyadh, Saudi Arabia.
Expert Rev Proteomics ; 20(7-9): 151-169, 2023.
Article in En | MEDLINE | ID: mdl-37766616
INTRODUCTION: Cystic fibrosis (CF) is a genetic disease characterized by thick and sticky mucus accumulation, which may harm numerous internal organs. Various variables such as gene modifiers, environmental factors, age of diagnosis, and CF transmembrane conductance regulator (CFTR) gene mutations influence phenotypic disease diversity. Biomarkers that are based on genomic information may not accurately represent the underlying mechanism of the disease as well as its lethal complications. Therefore, recent advancements in mass spectrometry (MS)-based proteomics may provide deep insights into CF mechanisms and cellular functions by examining alterations in the protein expression patterns from various samples of individuals with CF. AREAS COVERED: We present current developments in MS-based proteomics, its application, and findings in CF. In addition, the future roles of proteomics in finding diagnostic and prognostic novel biomarkers. EXPERT OPINION: Despite significant advances in MS-based proteomics, extensive research in a large cohort for identifying and validating diagnostic, prognostic, predictive, and therapeutic biomarkers for CF disease is highly needed.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: Expert Rev Proteomics Journal subject: BIOQUIMICA Year: 2023 Document type: Article Affiliation country: Jordania Country of publication: Reino Unido

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Diagnostic_studies / Prognostic_studies Language: En Journal: Expert Rev Proteomics Journal subject: BIOQUIMICA Year: 2023 Document type: Article Affiliation country: Jordania Country of publication: Reino Unido