[Effects of 3D tissue structure on drug sensitivity - 3D bioprinted tissue mimetic structures in cancer research]. / 3D szöveti szerkezet hatása a gyógyszerérzékenységre 3D bionyomtatott "szövetmodellek" a daganatkutatásban.
Magy Onkol
; 67(3): 237-246, 2023 Sep 28.
Article
in Hu
| MEDLINE
| ID: mdl-37768119
ABSTRACT
The issues surrounding the cost effectiveness of drug development and the ethical concerns associated with animal testing, emphasise the necessity for innovative in vitro models that allow enhanced pre-selection. Therefore, we aim to create 3D bioprinted tissue mimetic structures (TMS) utilizing various human cancer cell lines. We have generated TMSs from human tumour cell lines (breast, kidney, glioma), with detailed characterisation of the ZR75.1 cell line. In this study, the tissue heterogeneity, the growth rate, and the drug sensitivity of different in vitro and in vivo models were compared. Tissue formation occurs within the TMS after one week, with a tissue heterogeneity similar to in vivo growing tumours. Moreover, TMSs exhibit similar drug sensitivity to that observed in vivo. In summary, the established 3D bioprinted TMSs represent an advanced in vitro model, which can contribute to achieve a more effective and ethical drug development process in the field of oncology.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glioma
Type of study:
Diagnostic_studies
Aspects:
Ethics
Limits:
Animals
/
Humans
Language:
Hu
Journal:
Magy Onkol
Journal subject:
NEOPLASIAS
Year:
2023
Document type:
Article
Affiliation country:
Hungria