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Overview of New Targets for Hepatitis B Virus: Immune Modulators, Interferons, Bifunctional Peptides, Therapeutic Vaccines and Beyond.
Lok, James; Guerra Veloz, Maria Fernanda; Agarwal, Kosh.
Affiliation
  • Lok J; Institute of Liver Studies, King's College Hospital, London, SE5 9RS, UK.
  • Guerra Veloz MF; Institute of Liver Studies, King's College Hospital, London, SE5 9RS, UK.
  • Agarwal K; Institute of Liver Studies, King's College Hospital, London, SE5 9RS, UK. Electronic address: kosh.agarwal@kcl.ac.uk.
Clin Liver Dis ; 27(4): 857-876, 2023 11.
Article in En | MEDLINE | ID: mdl-37778774
ABSTRACT
Nucleos(t)ide analogs are the cornerstone of treatment against hepatitis B virus; however, they have no direct effect on its transcriptional template (ie, covalently closed circular DNA) and so functional cure is rarely achieved. Over recent years, there has been a significant improvement in our understanding of the viral life cycle and its mechanisms of immune evasion. In this review article, we will explore novel therapeutic targets, discuss the latest data from clinical trials, and highlight future research priorities.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vaccines / Hepatitis B, Chronic / Hepatitis B Limits: Humans Language: En Journal: Clin Liver Dis Journal subject: GASTROENTEROLOGIA Year: 2023 Document type: Article Affiliation country: Reino Unido
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Vaccines / Hepatitis B, Chronic / Hepatitis B Limits: Humans Language: En Journal: Clin Liver Dis Journal subject: GASTROENTEROLOGIA Year: 2023 Document type: Article Affiliation country: Reino Unido