Associations Between Sleep Traits and Social Isolation: Observational and Bidirectional Mendelian Randomization Study.
J Gerontol A Biol Sci Med Sci
; 79(1)2024 Jan 01.
Article
in En
| MEDLINE
| ID: mdl-37779488
ABSTRACT
Social isolation has been found associated with multiple sleep traits in conventional observational studies. However, whether this association is causal and if so, its direction is uncertain. We analyzed the association between social isolation and multiple sleep traits in 30 430 participants from the Guangzhou Biobank Cohort Study. In bidirectional Mendelian randomization, we used 6, 17, and 11 single nucleotide polymorphisms associated with attendance at sports club/gym, religious group, and pub/social club from the UK Biobank (n = 452 302), respectively, and 152 single nucleotide polymorphisms associated with insomnia from the combination of UK Biobank and 23andme (n = 1 331 010). Observationally in the Guangzhou Biobank Cohort Study, insomnia (yes/no) (beta = 0.12, 95% confidence interval (CI) 0.10-0.16) and poor sleep quality (yes/no) (beta = 0.12, CI 0.08-0.15), but not sleep duration and chronotype, were associated with a higher social isolation score (severe social isolation). In bidirectional MR, genetically predicted insomnia decreases the odds of attendance at sports club/gym (beta = 0.98, CI 0.98-0.99) and religious groups (beta = 0.99, CI 0.98-0.99), but not pub/social club. However, these 3 types of social activity were not associated with insomnia. Our results support the causal effects of insomnia on social activity. Further clinical investigations into the utility of insomnia treatment in alleviating social isolation are needed.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sleep Initiation and Maintenance Disorders
Type of study:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Aspects:
Determinantes_sociais_saude
Limits:
Humans
Language:
En
Journal:
J Gerontol A Biol Sci Med Sci
Journal subject:
GERIATRIA
Year:
2024
Document type:
Article
Affiliation country:
China
Publication country:
EEUU
/
ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
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EUA
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UNITED STATES
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UNITED STATES OF AMERICA
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US
/
USA