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Imbalance of thalamic metabolites in an experimental model of hypertension: role of bergamot polyphenols.
Carresi, Cristina; Cardamone, Antonio; Coppoletta, Anna Rita; Mollace, Annachiara; Musolino, Vincenzo; Gliozzi, Micaela; Mollace, Vincenzo.
Affiliation
  • Carresi C; Veterinary Pharmacology Laboratory, Department of Health Sciences, Interregional Research Center for Food Safety and Health IRC-FSH, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
  • Cardamone A; Pharmacology Laboratory, Department of Health Sciences, Interregional Research Center for Food Safety and Health IRC-FSH, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
  • Coppoletta AR; Pharmacology Laboratory, Department of Health Sciences, Interregional Research Center for Food Safety and Health IRC-FSH, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
  • Mollace A; Pharmacology Laboratory, Department of Health Sciences, Interregional Research Center for Food Safety and Health IRC-FSH, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
  • Musolino V; Pharmaceutical Biology Laboratory, Department of Health Sciences, Interregional Research Center for Food Safety and Health IRC-FSH, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
  • Gliozzi M; Pharmacology Laboratory, Department of Health Sciences, Interregional Research Center for Food Safety and Health IRC-FSH, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
  • Mollace V; Pharmacology Laboratory, Department of Health Sciences, Interregional Research Center for Food Safety and Health IRC-FSH, University "Magna Græcia" of Catanzaro, Catanzaro, Italy.
Front Integr Neurosci ; 17: 1271005, 2023.
Article in En | MEDLINE | ID: mdl-37780094
ABSTRACT
Cerebral metabolites are associated with different physiological and pathological processes in brain tissue. Among them, the concentrations of N-acetylaspartate (NAA) and choline-containing compounds (Cho) in the thalamic region are recognized and analyzed as important predictive markers of brain impairment. The relationship among hypertension, modulation of brain metabolite levels and cerebral diseases is of recent investigation, leaving many unanswered questions regarding the origin and consequences of the metabolic damage caused in grey and white matter during hypertension. Here we provide evidence for the influence of hypertension on NAA and Cho ratios in hypertensive rat thalamus and how the use of natural occurring compounds ameliorates the balance of thalamic metabolites.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Front Integr Neurosci Year: 2023 Document type: Article Affiliation country: Italia
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Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: Front Integr Neurosci Year: 2023 Document type: Article Affiliation country: Italia