Introduction to pharmacogenetics.
Drug Ther Bull
; 61(11): 168-172, 2023 Nov.
Article
in En
| MEDLINE
| ID: mdl-37788890
ABSTRACT
There is considerable interindividual variability in the effectiveness and safety of medicines. Although the reasons for this are multifactorial, it is well recognised that genetic changes impacting the absorption or metabolism of these drugs play a significant contributory role. Understanding how these pharmacogenetic variants impact response to medicines, and leveraging this knowledge to guide prescribing, could have significant benefits for patients and health services. This article provides an introduction to the field of pharmacogenetics, including its nomenclature, the existing evidence base and the current state of implementation globally. We discuss the challenges in translating pharmacogenetic research into clinical practice and highlight the considerable benefits which can emerge in those health services where implementation is successful.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pharmacogenetics
Limits:
Humans
Language:
En
Journal:
Drug Ther Bull
Year:
2023
Document type:
Article
Affiliation country:
Reino Unido