Efficacy of ceftaroline and rifampin, alone or combined, in a rat model of methicillin-resistant Staphylococcus epidermidis osteomyelitis without implant.
Microbiol Spectr
; 11(6): e0015323, 2023 Dec 12.
Article
in En
| MEDLINE
| ID: mdl-37791959
ABSTRACT
IMPORTANCE Methicillin-resistant Staphylococcus epidermidis (MRSE) contributes to a high percentage of orthopedic infections, and their treatment represents a huge challenge. The present study aimed to evaluate the efficacy of ceftaroline alone or combined with rifampin in a rat MRSE osteomyelitis model and the bone penetration of ceftaroline. A ceftaroline monotherapy showed a significant bacterial reduction in infected bones after a 7-day period of treatment. The combination ceftaroline plus rifampin leveraged rifampin's bactericidal activity, shortening the duration of positive culture in infected animals. These results suggest that ceftaroline and rifampin combination therapy could represent a valuable therapeutic option for human MRSE osteomyelitis and deserves further preclinical and clinical evaluation.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteomyelitis
/
Staphylococcal Infections
/
Methicillin-Resistant Staphylococcus aureus
Limits:
Animals
/
Humans
Language:
En
Journal:
Microbiol Spectr
Year:
2023
Document type:
Article
Affiliation country:
Francia