Effect of awake prone positioning on tracheal intubation rates in patients with COVID-19: A meta-analysis.
Heliyon
; 9(9): e19633, 2023 Sep.
Article
in En
| MEDLINE
| ID: mdl-37809914
ABSTRACT
Purpose:
We investigated the effect of awake prone positioning on endotracheal intubation rates in spontaneously breathing patients with COVID-19 not undergoing endotracheal intubation.Methods:
We searched the CINAHL, Cochrane Library, PUBMED, MEDLINE, and Web of Science databases until December 31, 2022. Prospective randomized controlled, cohort, and case-control studies were included. A meta-analysis was performed on the primary outcome measure, tracheal intubation rates, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.Results:
Ten studies with a total of 2641 patients were included. The tracheal intubation rate in the awake prone position was 34% (95%CI 0.59-1.10; P = 0.18; I2 = 55%), showing a non-significant benefit. Mortality was lower in prone-positioned than in supine-positioned patients (odds ratio 0.75; 95% CI 0.61-0.93; P = 0.007; I2 = 46%), prone positioning significantly improved the PaO2/FiO2 ratio (mean difference -29.17; 95%CI -50.91 to -7.43; P = 0.009; I2 = 44%).Conclusions:
Prone positioning can improve the PaO2/FIO2 ratio in patients with COVID-19 but we found no significant effect on tracheal intubation rates. Awake prone positioning seems to be associated with lower mortality, however, and may thus be a beneficial and effective intervention for patients with COVID-19. The optimal timing, duration, and target population need to be determined in future studies.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
/
Systematic_reviews
Language:
En
Journal:
Heliyon
Year:
2023
Document type:
Article
Affiliation country:
China