Structural and functional diversity of type IV secretion systems.
Nat Rev Microbiol
; 22(3): 170-185, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-37814112
ABSTRACT
Considerable progress has been made in recent years in the structural and molecular biology of type IV secretion systems in Gram-negative bacteria. The latest advances have substantially improved our understanding of the mechanisms underlying the recruitment and delivery of DNA and protein substrates to the extracellular environment or target cells. In this Review, we aim to summarize these exciting structural and molecular biology findings and to discuss their functional implications for substrate recognition, recruitment and translocation, as well as the biogenesis of extracellular pili. We also describe adaptations necessary for deploying a breadth of processes, such as bacterial survival, host-pathogen interactions and biotic and abiotic adhesion. We highlight the functional and structural diversity that allows this extremely versatile secretion superfamily to function under different environmental conditions and in different bacterial species. Additionally, we emphasize the importance of further understanding the mechanism of type IV secretion, which will support us in combating antimicrobial resistance and treating type IV secretion system-related infections.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Fimbriae, Bacterial
/
Type IV Secretion Systems
Language:
En
Journal:
Nat Rev Microbiol
Journal subject:
MICROBIOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Reino Unido