Autophagy protects mitochondrial health in heart failure.
Heart Fail Rev
; 29(1): 113-123, 2024 Jan.
Article
in En
| MEDLINE
| ID: mdl-37823952
ABSTRACT
The progression of heart failure is reported to be strongly associated with homeostatic imbalance, such as mitochondrial dysfunction and abnormal autophagy, in the cardiomyocytes. Mitochondrial dysfunction triggers autophagic and cardiac dysfunction. In turn, abnormal autophagy impairs mitochondrial function and leads to apoptosis or autophagic cell death under certain circumstances. These events often occur concomitantly, forming a vicious cycle that exacerbates heart failure. However, the role of the crosstalk between mitochondrial dysfunction and abnormal autophagy in the development of heart failure remains obscure and the underlying mechanisms are mainly elusive. The potential role of the link between mitochondrial dysfunction and abnormal autophagy in heart failure progression has recently garnered attention. This review summarized recent advances of the interactions between mitochondria and autophagy during the development of heart failure.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mitochondrial Diseases
/
Heart Failure
Limits:
Humans
Language:
En
Journal:
Heart Fail Rev
Journal subject:
CARDIOLOGIA
Year:
2024
Document type:
Article
Affiliation country:
China