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Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.
Gall-Duncan, Terence; Luo, Jennifer; Jurkovic, Carla-Marie; Fischer, Laura A; Fujita, Kyota; Deshmukh, Amit L; Harding, Rachel J; Tran, Stephanie; Mehkary, Mustafa; Li, Vanessa; Leib, David E; Chen, Ran; Tanaka, Hikari; Mason, Amanda G; Lévesque, Dominique; Khan, Mahreen; Razzaghi, Mortezaali; Prasolava, Tanya; Lanni, Stella; Sato, Nozomu; Caron, Marie-Christine; Panigrahi, Gagan B; Wang, Peixiang; Lau, Rachel; Castel, Arturo López; Masson, Jean-Yves; Tippett, Lynette; Turner, Clinton; Spies, Maria; La Spada, Albert R; Campos, Eric I; Curtis, Maurice A; Boisvert, François-Michel; Faull, Richard L M; Davidson, Beverly L; Nakamori, Masayuki; Okazawa, Hitoshi; Wold, Marc S; Pearson, Christopher E.
Affiliation
  • Gall-Duncan T; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Luo J; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Jurkovic CM; Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC, Canada.
  • Fischer LA; Developmental Biology and Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO, USA.
  • Fujita K; Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
  • Deshmukh AL; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
  • Harding RJ; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada; Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.
  • Tran S; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Mehkary M; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Li V; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Leib DE; Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19146, USA.
  • Chen R; Pediatrics, Division of Hematology and Oncology, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Tanaka H; Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
  • Mason AG; Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
  • Lévesque D; Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC, Canada.
  • Khan M; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Razzaghi M; Biochemistry and Molecular Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
  • Prasolava T; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
  • Lanni S; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
  • Sato N; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
  • Caron MC; CHU de Québec-Université Laval, Oncology Division, Molecular Biology, Medical Biochemistry, and Pathology, Laval University Cancer Research Center, Québec, QC, Canada.
  • Panigrahi GB; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
  • Wang P; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
  • Lau R; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.
  • Castel AL; BIOTECMED, University of Valencia, Valencia, Spain.
  • Masson JY; CHU de Québec-Université Laval, Oncology Division, Molecular Biology, Medical Biochemistry, and Pathology, Laval University Cancer Research Center, Québec, QC, Canada.
  • Tippett L; School of Psychology, University of Auckland, Auckland, New Zealand; University Research Centre for Brain Research, University of Auckland, Auckland, New Zealand.
  • Turner C; Anatomical Pathology, LabPlus, Auckland City Hospital, Auckland, New Zealand.
  • Spies M; Biochemistry and Molecular Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
  • La Spada AR; Pathology & Laboratory Medicine, Neurology, and Biological Chemistry, University of California, Irvine School of Medicine, Irvine, CA, USA; Neurobiology & Behavior, University of California, Irvine, Irvine, CA, USA; Center for Neurotherapeutics, University of California, Irvine, Irvine, CA 9
  • Campos EI; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Molecular Genetics, University of Toronto, Toronto, ON, Canada.
  • Curtis MA; University Research Centre for Brain Research, University of Auckland, Auckland, New Zealand; Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.
  • Boisvert FM; Immunology and Cell Biology, Université de Sherbrooke, Sherbrooke, QC, Canada.
  • Faull RLM; University Research Centre for Brain Research, University of Auckland, Auckland, New Zealand; Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.
  • Davidson BL; Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19146, USA.
  • Nakamori M; Neurology, Osaka University Graduate School of Medicine, Osaka, Japan.
  • Okazawa H; Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
  • Wold MS; Biochemistry and Molecular Biology, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
  • Pearson CE; Genetics & Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada; Structural Genomics Consortium, University of Toronto, Toronto, ON M5G 1L7, Canada. Electronic address: cepearson.sickkids@gmail.com.
Cell ; 186(22): 4898-4919.e25, 2023 10 26.
Article in En | MEDLINE | ID: mdl-37827155
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trinucleotide Repeat Expansion / Replication Protein A Limits: Animals / Humans Language: En Journal: Cell Year: 2023 Document type: Article Affiliation country: Canadá
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Trinucleotide Repeat Expansion / Replication Protein A Limits: Animals / Humans Language: En Journal: Cell Year: 2023 Document type: Article Affiliation country: Canadá