Tick salivary glycans - a sugar-coated tick bite.
Trends Parasitol
; 39(12): 1100-1113, 2023 12.
Article
in En
| MEDLINE
| ID: mdl-37838514
ABSTRACT
Ticks are hematophagous arthropods that transmit disease-causing pathogens worldwide. Tick saliva deposited into the tick-bite site is composed of an array of immunomodulatory proteins that ensure successful feeding and pathogen transmission. These salivary proteins are often glycosylated, and glycosylation is potentially critical for the function of these proteins. Some salivary glycans are linked to the phenomenon of red meat allergy - an allergic response to red meat consumption in humans exposed to certain tick species. Tick salivary glycans are also invoked in the phenomenon of acquired tick resistance wherein non-natural host species exposed to tick bites develop an immune response that thwarts subsequent tick feeding. This review dwells on our current knowledge of these two phenomena, thematically linked by salivary glycans.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ticks
/
Tick Bites
/
Food Hypersensitivity
Limits:
Animals
/
Humans
Language:
En
Journal:
Trends Parasitol
Journal subject:
PARASITOLOGIA
Year:
2023
Document type:
Article
Affiliation country:
Estados Unidos