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[Effects of Cytokines on Early Death in Patients with Newly Diagnosed Acute Promyelocytic Leukemia].
Zhao, Shi-Xiang; Ge, Yuan-Yuan; Li, Zeng-Zheng; He, Hai-Ping; Shen, Cheng-Min; Shi, Ke-Qian; Yang, Tong-Hua; DU, Yun-Yun.
Affiliation
  • Zhao SX; Department of Hematology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650100, Yunnan Province, China.
  • Ge YY; Faculty of Life Science and Biotechnology, Kunming University of Science and Technology, Kunming 650500, Yunnan Province, China.
  • Li ZZ; Department of Cardiology, The 920th Hospital of Joint Logistics Support Force, Kunming 650032, Yunnan Province, China.
  • He HP; Department of Hematology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650100, Yunnan Province, China.
  • Shen CM; Department of Hematology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650100, Yunnan Province, China.
  • Shi KQ; Department of Hematology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650100, Yunnan Province, China.
  • Yang TH; Department of Hematology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650100, Yunnan Province, China.
  • DU YY; Department of Hematology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650100, Yunnan Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 31(5): 1315-1321, 2023 Oct.
Article in Zh | MEDLINE | ID: mdl-37846678
ABSTRACT

OBJECTIVE:

To explore the effect of cytokine levels on early death and coagulation function of patients with newly diagnosed acute promyelocytic leukemia (APL).

METHODS:

Routine examination was performed on 69 newly diagnosed APL patients at admission. Meanwhile, 4 ml fasting venous blood was extracted from the patients. And then the supernatant was taken after centrifugation. The concentrations of cytokines, lactate dehydrogenase (LDH) and ferritin were detected by using the corresponding kits.

RESULTS:

It was confirmed that cerebral hemorrhage was a major cause of early death in APL patients. Elevated LDH, decreased platelets (PLT) count and prolonged prothrombin time (PT) were high risk factors for early death (P <0.05). The increases of IL-5, IL-6, IL-10, IL-12p70 and IL-17A were closely related to the early death of newly diagnosed APL patients, and the increases of IL-5 and IL-17A also induced coagulation disorder in APL patients by prolonging PT (P <0.05). In newly diagnosed APL patients, ferritin and LDH showed a positive effect on the expression of IL-5, IL-10 and IL-17A, especially ferritin had a highly positive correlation with IL-5 (r =0.867) and IL-17A (r =0.841). Moreover, there was a certain correlation between these five high-risk cytokines, among which IL-5 and IL-17A (r =0.827), IL-6 and IL-10 (r =0.823) were highly positively correlated.

CONCLUSION:

Elevated cytokine levels in newly diagnosed APL patients increase the risk of early bleeding and death. In addition to the interaction between cytokines themselves, ferritin and LDH positively affect the expression of cytokines, thus affecting the prognosis of APL patients.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Coagulation Disorders / Leukemia, Promyelocytic, Acute Limits: Humans Language: Zh Journal: Zhongguo Shi Yan Xue Ye Xue Za Zhi Journal subject: HEMATOLOGIA Year: 2023 Document type: Article Affiliation country: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Blood Coagulation Disorders / Leukemia, Promyelocytic, Acute Limits: Humans Language: Zh Journal: Zhongguo Shi Yan Xue Ye Xue Za Zhi Journal subject: HEMATOLOGIA Year: 2023 Document type: Article Affiliation country: China