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Blocking of doublecortin-like kinase 1-regulated SARS-CoV-2 replication cycle restores cell signaling network.
Undi, Ram Babu; Ahsan, Nagib; Larabee, Jason L; Darlene-Reuter, Nicole; Papin, James; Dogra, Samrita; Hannafon, Bethany N; Bronze, Michael S; Houchen, Courtney W; Huycke, Mark M; Ali, Naushad.
Affiliation
  • Undi RB; Department of Radiation Oncology, University of Oklahoma Health Sciences Center , Oklahoma City, Oklahoma, USA.
  • Ahsan N; Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center , Oklahoma City, Oklahoma, USA.
  • Larabee JL; Department of Chemistry and Biochemistry, University of Oklahoma , Norman, Oklahoma, USA.
  • Darlene-Reuter N; Mass Spectrometry, Proteomics and Metabolomics Core Facility, Stephenson Life Sciences Research Center, University of Oklahoma , Norman, Oklahoma, USA.
  • Papin J; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, Oklahoma, USA.
  • Dogra S; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, Oklahoma, USA.
  • Hannafon BN; Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center , Oklahoma City, Oklahoma, USA.
  • Bronze MS; Department of Pathology, University of Oklahoma Health Sciences Center , Oklahoma City, Oklahoma, USA.
  • Houchen CW; Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center , Oklahoma City, Oklahoma, USA.
  • Huycke MM; Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center , Oklahoma City, Oklahoma, USA.
  • Ali N; Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center , Oklahoma City, Oklahoma, USA.
J Virol ; 97(11): e0119423, 2023 Nov 30.
Article in En | MEDLINE | ID: mdl-37861336
ABSTRACT
IMPORTANCE Severe COVID-19 and post-acute sequelae often afflict patients with underlying co-morbidities. There is a pressing need for highly effective treatment, particularly in light of the emergence of SARS-CoV-2 variants. In a previous study, we demonstrated that DCLK1, a protein associated with cancer stem cells, is highly expressed in the lungs of COVID-19 patients and enhances viral production and hyperinflammatory responses. In this study, we report the pivotal role of DCLK1-regulated mechanisms in driving SARS-CoV-2 replication-transcription processes and pathogenic signaling. Notably, pharmacological inhibition of DCLK1 kinase during SARS-CoV-2 effectively impedes these processes and counteracts virus-induced alternations in global cell signaling. These findings hold significant potential for immediate application in treating COVID-19.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 / Doublecortin-Like Kinases / COVID-19 Drug Treatment Limits: Humans Language: En Journal: J Virol Year: 2023 Document type: Article Affiliation country: Estados Unidos
Fulltext
Add to My VHL
Print
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 / Doublecortin-Like Kinases / COVID-19 Drug Treatment Limits: Humans Language: En Journal: J Virol Year: 2023 Document type: Article Affiliation country: Estados Unidos