People with HIV at the end-of-life and their next-of-kin/loved ones are willing to participate in interventional HIV cure-related research.
AIDS
; 38(2): 235-243, 2024 Feb 01.
Article
in En
| MEDLINE
| ID: mdl-37861674
ABSTRACT
INTRODUCTION:
The Last Gift study at the University of California San Diego (UCSD), United States enrolls terminally ill people with HIV (PWH) in HIV cure research.METHODS:
From 2017 to 2022, we conducted surveys with Last Gift participants and their next-of-kin/loved ones to evaluate willingness to participate in different types of HIV cure research at the end of life (EOL). We analyzed willingness data descriptively.RESULTS:
We surveyed 17 Last Gift participants and 17ânext-of-kin/loved ones. More than half of Last Gift participants ( n â=â10; 58.8%) expressed willingness to participate in studies involving totally new treatments or approaches ('first-in-human' studies), a combination of different approaches, the use of unique antibodies, proteins or molecules, or therapeutic vaccines. Under one-quarter of Last Gift participants ( n â=â4; 23.5%) expressed willingness to participate in research involving interventions that may shorten their life expectancy to benefit medical research. Most Last Gift participants and their next-of-kin/loved ones also expressed high acceptance for various types of donations and biopsies at the EOL (e.g. hair donations and skin, lymph node or gut biopsies).DISCUSSION:
Knowing whether people would be willing to participate in different types of EOL HIV cure research can help inform the design of future innovative studies. As a research community, we have a duty to design studies with adequate safeguards to preserve the public trust in research and honor PWH's important gift to humanity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
HIV Infections
Limits:
Humans
Country/Region as subject:
America do norte
Language:
En
Journal:
AIDS
Journal subject:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Year:
2024
Document type:
Article
Affiliation country:
Canadá