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Discovery of benzimidazole-indazole derivatives as potent FLT3-tyrosine kinase domain mutant kinase inhibitors for acute myeloid leukemia.
Ko, Bongki; Jang, Yongsoo; Kim, Min Ha; Lam, Thai Thi; Seo, Hye Kyung; Jeong, Pyeonghwa; Choi, Munkyung; Kang, Keon Wook; Lee, So-Deok; Park, Jin-Hee; Kim, Myungjin; Han, Sun-Young; Kim, Yong-Chul.
Affiliation
  • Ko B; School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, South Korea.
  • Jang Y; School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, South Korea.
  • Kim MH; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Gyeongsangnam-do, 52828, South Korea.
  • Lam TT; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Gyeongsangnam-do, 52828, South Korea.
  • Seo HK; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Gyeongsangnam-do, 52828, South Korea.
  • Jeong P; School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, South Korea.
  • Choi M; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, South Korea.
  • Kang KW; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 08826, South Korea.
  • Lee SD; R&D Center, PeLeMed, Co. Ltd, Seoul, 06100, South Korea.
  • Park JH; R&D Center, PeLeMed, Co. Ltd, Seoul, 06100, South Korea.
  • Kim M; R&D Center, PeLeMed, Co. Ltd, Seoul, 06100, South Korea.
  • Han SY; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Gyeongsangnam-do, 52828, South Korea. Electronic address: syhan@gnu.ac.kr.
  • Kim YC; School of Life Sciences, Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, South Korea; Center for AI-Applied High Efficiency Drug Discovery (AHEDD), Gwangju Institute of Science and Technology (GIST), Gwangju, 61005, South Korea; R&D Center, PeLeMed, Co. Ltd, Seoul, 06100, Sou
Eur J Med Chem ; 262: 115860, 2023 Dec 15.
Article in En | MEDLINE | ID: mdl-37866334
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Fms-Like Tyrosine Kinase 3 Limits: Humans Language: En Journal: Eur J Med Chem Year: 2023 Document type: Article Affiliation country: Corea del Sur
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia, Myeloid, Acute / Fms-Like Tyrosine Kinase 3 Limits: Humans Language: En Journal: Eur J Med Chem Year: 2023 Document type: Article Affiliation country: Corea del Sur