Clopidogrel vs Aspirin Monotherapy Beyond 1 Year After Percutaneous Coronary Intervention.
J Am Coll Cardiol
; 83(1): 17-31, 2024 Jan 02.
Article
in En
| MEDLINE
| ID: mdl-37879491
ABSTRACT
BACKGROUND:
It remains unclear whether clopidogrel is better suited than aspirin as the long-term antiplatelet monotherapy following dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI).OBJECTIVES:
This study compared clopidogrel monotherapy following 1 month of DAPT (clopidogrel group) with aspirin monotherapy following 12 months of DAPT (aspirin group) after PCI for 5 years.METHODS:
STOPDAPT-2 (Short and Optimal Duration of Dual Antiplatelet Therapy 2) is a multicenter, open-label, adjudicator-blinded, randomized clinical trial conducted in Japan. Patients who underwent PCI with cobalt-chromium everolimus-eluting stents were randomized in a 1-to-1 fashion either to clopidogrel or aspirin groups. The primary endpoint was a composite of cardiovascular outcomes (cardiovascular death, myocardial infarction, stroke, or definite stent thrombosis) or major bleeding (TIMI major or minor bleeding).RESULTS:
Among 3,005 study patients (age 68.6 ± 10.7 years; women 22.3%; acute coronary syndrome 38.3%), 2,934 patients (97.6%) completed the 5-year follow-up (adherence to the study drugs at 395 days 84.7% and 75.9%). The clopidogrel group compared with the aspirin group was noninferior but not superior for the primary endpoint (11.75% and 13.57%, respectively; HR 0.85; 95% CI 0.70-1.05; Pnoninferiority < 0.001; Psuperiority = 0.13), whereas it was superior for the cardiovascular outcomes (8.61% and 11.05%, respectively; HR 0.77; 95% CI 0.61-0.97; P = 0.03) and not superior for major bleeding (4.44% and 4.92%, respectively; HR 0.89; 95% CI 0.64-1.25; P = 0.51). By the 1-year landmark analysis, clopidogrel was numerically, but not significantly, superior to aspirin for cardiovascular events (6.79% and 8.68%, respectively; HR 0.77; 95% CI 0.59-1.01; P = 0.06) without difference in major bleeding (3.99% and 3.32%, respectively; HR 1.23; 95% CI 0.84-1.81; P = 0.31).CONCLUSIONS:
Clopidogrel might be an attractive alternative to aspirin with a borderline ischemic benefit beyond 1 year after PCI.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Aspirin
/
Percutaneous Coronary Intervention
Limits:
Aged
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
J Am Coll Cardiol
Year:
2024
Document type:
Article
Affiliation country:
Japón