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Live-cell target engagement of allosteric MEKi on MEK-RAF/KSR-14-3-3 complexes.
Marsiglia, William M; Chow, Arthur; Khan, Zaigham M; He, Liu; Dar, Arvin C.
Affiliation
  • Marsiglia WM; Department of Oncological Sciences, The Tisch Cancer Institute, Mount Sinai Center for Therapeutic Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, USA. wmmarsig@uab.edu.
  • Chow A; Department of Pharmacological Sciences, The Tisch Cancer Institute, Mount Sinai Center for Therapeutic Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, USA. wmmarsig@uab.edu.
  • Khan ZM; Department of Pharmacology and Toxicology, The University of Alabama at Birmingham, Birmingham, AL, USA. wmmarsig@uab.edu.
  • He L; Department of Oncological Sciences, The Tisch Cancer Institute, Mount Sinai Center for Therapeutic Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Dar AC; Department of Pharmacological Sciences, The Tisch Cancer Institute, Mount Sinai Center for Therapeutic Discovery, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nat Chem Biol ; 20(3): 373-381, 2024 Mar.
Article in En | MEDLINE | ID: mdl-37919548
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biological Assay / Proto-Oncogene Proteins B-raf Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2024 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biological Assay / Proto-Oncogene Proteins B-raf Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2024 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos