Clinical characteristics and therapeutic response of differentiated thyroid carcinoma with obesity and diabetes.
BMC Cancer
; 23(1): 1077, 2023 Nov 08.
Article
in En
| MEDLINE
| ID: mdl-37940857
ABSTRACT
BACKGROUND:
The effects of obesity and diabetes on the clinical outcomes of differentiated thyroid cancer (DTC) remain unclear.OBJECTIVES:
To explore the association between obesity and diabetes with pathological features and therapeutic response of DTC.METHODS:
Patients were categorized based on body mass index (BMI) and glycemic status. Compare the correlation between BMI and glycemic status with pathological features and therapeutic response of DTC. To analyze the independent risk factors for the aggressiveness of DTC.RESULTS:
The proportion of patients with bilateral tumors was higher in the overweight, obese and diabetes group (P = 0.001, 0.045). The overweight group demonstrated a higher TNM stage (P = 0.004), while the T and TNM stages were higher in the diabetes group (P = 0.032, 0.000). The probability of distant metastasis increases by 37.4% for each unit of BMI increase (odds ratio (OR) = 1.374, CI 95% 1.061-1.778, P < 0.05). The BMI of Biochemical Incomplete Response (BIR) is significantly higher than that of Excellent Response (ER) (P = 0.015), the fasting plasma glucose (FPG) of Structural Incomplete (SIR) was significantly higher than that of ER and BIR (P = 0.030, 0.014).CONCLUSION:
Obesity and diabetes have effect on DTC aggressiveness. BMI and FPG have correlation with the therapeutic response of DTC patients.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thyroid Neoplasms
/
Adenocarcinoma
/
Diabetes Mellitus
Limits:
Humans
Language:
En
Journal:
BMC Cancer
Journal subject:
NEOPLASIAS
Year:
2023
Document type:
Article
Affiliation country:
China