Levels of vitamin D and a bone resorption marker in the sera of young women with alcohol use disorder.
J Addict Dis
; : 1-9, 2023 Nov 11.
Article
in En
| MEDLINE
| ID: mdl-37950604
ABSTRACT
BACKGROUND:
Excessive alcohol drinking negatively affects bone metabolism and leads to a risk of decreased bone mass, which is a major component of the pathogenesis of osteoporosis. However, the potential influence of alcohol on bones has not been fully recognized, particularly among the young to middle-aged generation.OBJECTIVES:
This study aimed to investigate the status of serum markers related to bone metabolism in young to middle-aged women with alcohol use disorder (AUD).METHODS:
Levels of vitamin D and the bone-resorption marker tartrate-resistant acid phosphatase 5b were measured in the sera of 25 women with AUD (mean age, 39.5 ± 7.5 years) who were enrolled in an AUD rehabilitation program. Data of samples obtained on admission and those after eight weeks were compared.RESULTS:
Of the 25 women with AUD, 19 (76%) had vitamin D deficiency (<20 ng/mL), and most of the patients showed relatively higher tartrate-resistant acid phosphatase 5b levels at baseline considering their premenopausal age. Although the levels did not change significantly at week eight of the AUD rehabilitation program, vitamin D levels tended to increase initially in patients with vitamin D deficiency. Although further investigations and detailed nutritional assessment are necessary, the results of this study may support the presence of a relatively unknown influence of AUD on the bone health of the young to middle-aged population. Along with psychological and physical care, persons with AUD should be treated as a high-risk group for future osteoporosis regardless of age.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
J Addict Dis
Journal subject:
TRANSTORNOS RELACIONADOS COM SUBSTANCIAS
Year:
2023
Document type:
Article
Affiliation country:
Japón