[Relationship between the neutrophil-to-lymphocyte ratio and estimated glomerular filtration rate in patients with primary aldosteronism: a cross-sectional study].
Zhonghua Xin Xue Guan Bing Za Zhi
; 51(11): 1145-1151, 2023 Nov 24.
Article
in Zh
| MEDLINE
| ID: mdl-37963749
ABSTRACT
Objective:
To investigate the associations between neutrophil-to-lymphocyte ratio (NLR) and estimated glomerular filtration rate (eGFR) in patients with primary aldosteronism (PA).Methods:
This study was a cross-sectional study. Consecutive patients diagnosed with PA and admitted to the Second Affiliated Hospital of Nanchang University from October 2017 to April 2022 were enrolled. General information, blood routine, renal function, and other clinical data of the patients were collected. Based on the median NLR of the enrolled patients, NLRResults:
This study finally included 743 PA patients, aged (50.3±10.4) years, 42.9% (319/743) were female, and the median NLR was 2.3. After adjusting for sex, age, body mass index (BMI) and other factors, multiple linear regression analysis showed that high NLR was negatively correlated with eGFR (ß=-4.9, P=0.008), and multivariate logistic regression analysis showed that high NLR was associated with low eGFR (OR=3.1, P=0.002). In the corrected smooth curve, NLR is U-shaped correlation with eGFR, and the inflection point is at NLR=3.5. When the NLR was<3.5, the eGFR decreased with the increase of NLR (corrected ß=-4.7, P<0.001); When the NLR was≥3.5, the eGFR increased with the increase of NLR (corrected ß=5.8, P=0.031). The results of stratified analysis showed that there was an interaction between the association of NLR and eGFR with the presence or absence of hyperlipidemia (P interaction=0.017), and the correlation between NLR and eGFR was stronger in PA patients with hyperlipidemia.Conclusion:
In the PA patients, there is a U-shaped relationship between NLR and eGFR, and higher NLR is associated with lower eGFR. PA patients with elevated NLR should undergo additional screening for chronic kidney disease and receive related preventive interventions.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hyperaldosteronism
/
Hyperlipidemias
Limits:
Female
/
Humans
/
Male
Language:
Zh
Journal:
Zhonghua Xin Xue Guan Bing Za Zhi
Year:
2023
Document type:
Article
Affiliation country:
China