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Targeted suppression of mTORC2 reduces seizures across models of epilepsy.
Okoh, James; Mays, Jacqunae; Bacq, Alexandre; Oses-Prieto, Juan A; Tyanova, Stefka; Chen, Chien-Ju; Imanbeyev, Khalel; Doladilhe, Marion; Zhou, Hongyi; Jafar-Nejad, Paymaan; Burlingame, Alma; Noebels, Jeffrey; Baulac, Stephanie; Costa-Mattioli, Mauro.
Affiliation
  • Okoh J; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
  • Mays J; Memory and Brain Research Center, Baylor College of Medicine, Houston, TX, USA.
  • Bacq A; Altos Labs Inc, Bay Area Institute, Redwood City, CA, USA.
  • Oses-Prieto JA; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
  • Tyanova S; Memory and Brain Research Center, Baylor College of Medicine, Houston, TX, USA.
  • Chen CJ; Institut du Cerveau-Paris Brain Institute-ICM, Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié Salpêtrière, F-75013, Paris, France.
  • Imanbeyev K; Departments of Chemistry and Pharmaceutical Chemistry, University of California San Fransisco, San Fransisco, CA, USA.
  • Doladilhe M; Altos Labs Inc, Bay Area Institute, Redwood City, CA, USA.
  • Zhou H; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
  • Jafar-Nejad P; Memory and Brain Research Center, Baylor College of Medicine, Houston, TX, USA.
  • Burlingame A; Novartis Inc, Boston, MA, USA.
  • Noebels J; Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA.
  • Baulac S; Memory and Brain Research Center, Baylor College of Medicine, Houston, TX, USA.
  • Costa-Mattioli M; Institut du Cerveau-Paris Brain Institute-ICM, Sorbonne Université, Inserm, CNRS, Hôpital de la Pitié Salpêtrière, F-75013, Paris, France.
Nat Commun ; 14(1): 7364, 2023 11 14.
Article in En | MEDLINE | ID: mdl-37963879
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epilepsy / TOR Serine-Threonine Kinases Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Epilepsy / TOR Serine-Threonine Kinases Limits: Animals / Humans Language: En Journal: Nat Commun Journal subject: BIOLOGIA / CIENCIA Year: 2023 Document type: Article Affiliation country: Estados Unidos Country of publication: Reino Unido