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Omics sciences and precision medicine in melanoma.
Medori, M C; Donato, K; Dhuli, K; Maltese, P E; Tanzi, B; Tezzele, S; Mareso, C; Miertus, J; Generali, D; Donofrio, C A; Cominetti, M; Fioravanti, A; Riccio, L; Beccari, T; Ceccarini, M R; Gisondi, P; Bellinato, F; Stuppia, L; Gatta, V; Cecchin, S; Marceddu, G; Bertelli, M.
Affiliation
  • Medori MC; MAGI'S LAB, Rovereto (TN), Italy.
  • Donato K; MAGI EUREGIO, Bolzano, Italy.
  • Dhuli K; MAGISNAT, Atlanta Tech Park, Peachtree Corners (GA), USA.
  • Maltese PE; MAGI'S LAB, Rovereto (TN), Italy.
  • Tanzi B; MAGI'S LAB, Rovereto (TN), Italy.
  • Tezzele S; MAGI'S LAB, Rovereto (TN), Italy.
  • Mareso C; MAGI'S LAB, Rovereto (TN), Italy.
  • Miertus J; MAGI EUREGIO, Bolzano, Italy.
  • Generali D; MAGI'S LAB, Rovereto (TN), Italy.
  • Donofrio CA; Department of Medicine, Surgery and Health Sciences, University of Trieste, Italy; Multidisciplinary Unit of Breast Pathology and Translational Research, Cremona Hospital, Italy.
  • Cominetti M; Department of Neurosurgery, ASST Cremona, Italy.
  • Fioravanti A; Division of Biology and Genetics, Department of Molecular and Translational Medicine, University of Brescia, Italy.
  • Riccio L; Department of Neurosurgery, ASST Cremona, Italy.
  • Beccari T; Department of Neurosurgery, ASST Cremona, Italy.
  • Ceccarini MR; Department of Neurosurgery, ASST Cremona, Italy.
  • Gisondi P; Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
  • Bellinato F; Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy.
  • Stuppia L; Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.
  • Gatta V; Section of Dermatology and Venereology, Department of Medicine, University of Verona, Verona, Italy.
  • Cecchin S; Department of Psychological Health and Territorial Sciences, School of Medicine and Health Sciences, "G. d'Annunzio" University of Chieti-Pescara, Italy.
  • Marceddu G; Unit of Molecular Genetics, Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University of Chieti-Pescara, Italy.
  • Bertelli M; Department of Psychological Health and Territorial Sciences, School of Medicine and Health Sciences, "G. d'Annunzio" University of Chieti-Pescara, Italy.
Clin Ter ; 174(Suppl 2(6)): 29-36, 2023.
Article in En | MEDLINE | ID: mdl-37994746
ABSTRACT

Background:

This article provides an overview of the application of omics sciences in melanoma research. The name omics sciences refers to the large-scale analysis of biological molecules like DNA, RNA, proteins, and metabolites.

Methods:

In the course of this review, we have adopted a focu-sed research strategy, meticulously selecting the most pertinent and emblematic articles related to the topic. Our methodology included a systematic examination of the scientific literature to guarantee a thorough and precise synthesis of the existing sources.

Results:

With the advent of high-throughput technologies, omics have become an essential tool for understanding the complexity of melanoma. In this article, we discuss the different omics approaches used in melanoma research, including genomics, transcriptomics, proteomics, and metabolomics. We also highlight the major findings and insights gained from these studies, including the identification of new therapeutic targets and the development of biomarkers for diagnosis and prognosis. Finally, we discuss the challenges and future directions in omics-based melanoma research, including the integration of multiple omics data and the development of personalized medicine approaches.

Conclusions:

Overall, this article emphasizes the importance of omics science in advancing our understanding of melanoma and its potential for improving patient outcomes.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precision Medicine / Melanoma Limits: Humans Language: En Journal: Clin Ter Year: 2023 Document type: Article Affiliation country: Italia

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Precision Medicine / Melanoma Limits: Humans Language: En Journal: Clin Ter Year: 2023 Document type: Article Affiliation country: Italia