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Effects of Cognitive Training on Alzheimer's Disease and Related Dementias: The Moderating Role of Social Determinants of Health.
Rebok, George W; Gellert, Andrew; Coe, Norma B; Clay, Olivio J; Wallace, Gail; Parisi, Jeanine M; Aiken-Morgan, Adrienne T; Crowe, Michael; Ball, Karlene; Thorpe, Roland J; Marsiske, Michael; Zahodne, Laura B; Felix, Cynthia; Willis, Sherry L.
Affiliation
  • Rebok GW; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Gellert A; Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research, Johns Hopkins University, Baltimore, MD, USA.
  • Coe NB; Johns Hopkins Center on Aging and Health, Johns Hopkins University, Baltimore, MD, USA.
  • Clay OJ; TIAA Institute, New York, NY, USA.
  • Wallace G; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  • Parisi JM; Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Aiken-Morgan AT; Deep South Resource Center for Minority Aging Research, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Crowe M; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Ball K; Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research, Johns Hopkins University, Baltimore, MD, USA.
  • Thorpe RJ; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
  • Marsiske M; Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research, Johns Hopkins University, Baltimore, MD, USA.
  • Zahodne LB; Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
  • Felix C; Department of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Willis SL; Deep South Resource Center for Minority Aging Research, University of Alabama at Birmingham, Birmingham, AL, USA.
J Aging Health ; 35(9_suppl): 40S-50S, 2023 10.
Article in En | MEDLINE | ID: mdl-37994850
ABSTRACT

Objective:

We examined whether social determinants of health (SDoH) are associated with Alzheimer's disease and related dementias (ADRD) risk and the effects of cognitive training over a 20-year follow-up period.

Methods:

Data were obtained from 1605 participants in ACTIVE. SDoH measures were created using baseline data at the individual and neighborhood level. Incident ADRD was defined using administrative claims data (1999-2019). Cause-specific hazard models estimated associations between SDoH and claims-based diagnosed ADRD.

Results:

Higher scores on neighborhood and built environment were associated with lower ADRD risk. Trained participants obtained a greater degree of protection from ADRD when they had higher scores for SDoH domains associated with health care and education access. However, there were fewer significant SDoH moderation effects on cognitive training than expected.

Discussion:

Future work should continue to explore culturally tailored cognitive training interventions to reduce ADRD risk associated with SDoH that disproportionately affects racially diverse aging populations.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alzheimer Disease / Cognitive Training Limits: Humans Language: En Journal: J Aging Health Journal subject: GERIATRIA Year: 2023 Document type: Article Affiliation country: Estados Unidos
Fulltext
Add to My VHL
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alzheimer Disease / Cognitive Training Limits: Humans Language: En Journal: J Aging Health Journal subject: GERIATRIA Year: 2023 Document type: Article Affiliation country: Estados Unidos