Pregnancy-responsive pools of adult neural stem cells for transient neurogenesis in mothers.
Science
; 382(6673): 958-963, 2023 11 24.
Article
in En
| MEDLINE
| ID: mdl-37995223
ABSTRACT
Adult neural stem cells (NSCs) contribute to lifelong brain plasticity. In the adult mouse ventricular-subventricular zone, NSCs are heterogeneous and, depending on their location in the niche, give rise to different subtypes of olfactory bulb (OB) interneurons. Here, we show that multiple regionally distinct NSCs, including domains that are usually quiescent, are recruited on different gestation days during pregnancy. Synchronized activation of these adult NSC pools generates transient waves of short-lived OB interneurons, especially in layers with less neurogenesis under homeostasis. Using spatial transcriptomics, we identified molecular markers of pregnancy-associated interneurons and showed that some subsets are temporarily needed for own pup recognition. Thus, pregnancy triggers transient yet behaviorally relevant neurogenesis, highlighting the physiological relevance of adult stem cell heterogeneity.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Olfactory Bulb
/
Smell
/
Pregnancy
/
Lateral Ventricles
/
Neurogenesis
/
Interneurons
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Maternal Behavior
/
Neuronal Plasticity
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Science
Year:
2023
Document type:
Article
Affiliation country:
Suiza
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
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US
/
USA