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COVID-19 convalescent plasma therapy decreases inflammatory cytokines: a randomized controlled trial.
Habtehyimer, Feben; Zhu, Xianming; Redd, Andrew D; Gebo, Kelly A; Abraham, Alison G; Patel, Eshan U; Laeyendecker, Oliver; Gniadek, Thomas J; Fernandez, Reinaldo E; Baker, Owen R; Ram, Malathi; Cachay, Edward R; Currier, Judith S; Fukuta, Yuriko; Gerber, Jonathan M; Heath, Sonya L; Meisenberg, Barry; Huaman, Moises A; Levine, Adam C; Shenoy, Aarthi; Anjan, Shweta; Blair, Janis E; Cruser, Daniel; Forthal, Donald N; Hammitt, Laura L; Kassaye, Seble; Mosnaim, Giselle S; Patel, Bela; Paxton, James H; Raval, Jay S; Sutcliffe, Catherine G; Abinante, Matthew; Oei, Kevin S; Cluzet, Valerie; Cordisco, Marie Elena; Greenblatt, Benjamin; Rausch, William; Shade, David; Gawad, Amy L; Klein, Sabra L; Pekosz, Andrew; Shoham, Shmuel; Casadevall, Arturo; Bloch, Evan M; Hanley, Daniel; Tobian, Aaron A R; Sullivan, David J.
Affiliation
  • Habtehyimer F; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.
  • Zhu X; Department of Pathology, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.
  • Redd AD; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.
  • Gebo KA; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Baltimore, Maryland, USA.
  • Abraham AG; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.
  • Patel EU; Department of Epidemiology, University of Colorado, Anschutz Medical Campus , Aurora, Colorado, USA.
  • Laeyendecker O; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.
  • Gniadek TJ; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Baltimore, Maryland, USA.
  • Fernandez RE; Department of Pathology and Laboratory Medicine, Northshore University Health System , Evanston, Illinois, USA.
  • Baker OR; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.
  • Ram M; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.
  • Cachay ER; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.
  • Currier JS; Department of Medicine, Division of Infectious Diseases, University of California, San Diego , San Diego, California, USA.
  • Fukuta Y; Department of Medicine, Division of Infectious Diseases, University of California, Los Angeles , Los Angeles, California, USA.
  • Gerber JM; Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine , Houston, Texas, USA.
  • Heath SL; Department of Medicine, Division of Hematology and Oncology, University of Massachusetts Chan Medical School , Worcester, Massachusetts, USA.
  • Meisenberg B; Department of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham , Birmingham, Alabama, USA.
  • Huaman MA; Department of Medicine and Research Institute of Luminis Health , Annapolis, Maryland, USA.
  • Levine AC; Department of Medicine, Division of Infectious Diseases, University of Cincinnati , Cincinnati, Ohio, USA.
  • Shenoy A; Department of Emergency Medicine, Warren Alpert Medical School of Brown University , Providence, Rhode Island, USA.
  • Anjan S; Department of Medicine, Division of Hematology and Oncology, MedStar Washington Hospital Center , Washington, DC, USA.
  • Blair JE; Department of Medicine, Division of Infectious Diseases, University of Miami, Miller School of Medicine , Miami, Florida, USA.
  • Cruser D; Department of Medicine, Division of Infectious Diseases, Mayo Clinic Hospital , Phoenix, Arizona, USA.
  • Forthal DN; Department of Pathology, Nuvance Health Vassar Brothers Medical Center , Poughkeepsie, New York, USA.
  • Hammitt LL; Department of Medicine, Division of Infectious Diseases, University of California, Irvine , Irvine, California, USA.
  • Kassaye S; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.
  • Mosnaim GS; Division of Infectious Diseases, Georgetown University Medical Center , Washington, DC, USA.
  • Patel B; Department of Medicine, Division of Allergy and Immunology, Northshore University Health System , Evanston, Illinois, USA.
  • Paxton JH; Department of Medicine, Divisions of Pulmonary and Critical Care Medicine, University of Texas Health Science Center , Houston, Texas, USA.
  • Raval JS; Department of Emergency Medicine, Wayne State University , Detroit, Michigan, USA.
  • Sutcliffe CG; Department of Pathology, University of New Mexico , Albuquerque, New Mexico, USA.
  • Abinante M; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.
  • Oei KS; Ascada Research , Fullerton, California, USA.
  • Cluzet V; Ascada Research , Fullerton, California, USA.
  • Cordisco ME; Department of Infectious Disease, Nuvance Health Vassar Brothers Medical Center , Poughkeepsie, New York, USA.
  • Greenblatt B; Nuvance Health Danbury Hospital , Danbury, Connecticut, USA.
  • Rausch W; Nuvance Health Norwalk Hospital , Norwalk, Connecticut, USA.
  • Shade D; Nuvance Health Danbury Hospital , Danbury, Connecticut, USA.
  • Gawad AL; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.
  • Klein SL; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.
  • Pekosz A; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.
  • Shoham S; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.
  • Casadevall A; Department of Medicine, Division of Infectious Diseases, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.
  • Bloch EM; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University , Baltimore, Maryland, USA.
  • Hanley D; Department of Pathology, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.
  • Tobian AAR; Department of Neurology, Brain Injury Outcomes Division, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.
  • Sullivan DJ; Department of Pathology, Johns Hopkins School of Medicine, Johns Hopkins University , Baltimore, Maryland, USA.
Microbiol Spectr ; 12(1): e0328623, 2024 Jan 11.
Article in En | MEDLINE | ID: mdl-38009954
ABSTRACT
IMPORTANCE This study examined the role that cytokines may have played in the beneficial outcomes found when outpatient individuals infected with SARS-CoV-2 were transfused with COVID-19 convalescent plasma (CCP) early in their infection. We found that the pro-inflammatory cytokine IL-6 decreased significantly faster in patients treated early with CCP. Participants with COVID-19 treated with CCP later in the infection did not have the same effect. This decrease in IL-6 levels after early CCP treatment suggests a possible role of inflammation in COVID-19 progression. The evidence of IL-6 involvement brings insight into the possible mechanisms involved in CCP treatment mitigating SARS-CoV-2 severity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: En Journal: Microbiol Spectr Year: 2024 Document type: Article Affiliation country: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: COVID-19 Limits: Humans Language: En Journal: Microbiol Spectr Year: 2024 Document type: Article Affiliation country: Estados Unidos