Targeting the pyruvate dehydrogenase complex/pyruvate dehydrogenase kinase (PDC/PDK) axis to discover potent PDK inhibitors through structure-based virtual screening and pharmacological evaluation.

Gan, Linling; Yang, Ying; Liang, Zizhen; Zhang, Maojie; He, Yun; Zhang, Shao-Lin

Gan, Linling; Yang, Ying; Liang, Zizhen; Zhang, Maojie; He, Yun; Zhang, Shao-Lin.

Affiliation

Gan L; Chongqing Engineering Research Center of Pharmaceutical Sciences, School of Pharmacy, Chongqing Medical and Pharmaceutical College, Chongqing, 401331, PR China.
Yang Y; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China.
Liang Z; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China.
Zhang M; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China.
He Y; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China. Electronic address: yun.he@cqu.edu.cn.
Zhang SL; School of Pharmaceutical Sciences, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chongqing University, Chongqing, 401331, PR China. Electronic address: zhangsl@cqu.edu.cn.

Eur J Med Chem ; 264: 116008, 2024 Jan 15.

Article in En | MEDLINE | ID: mdl-38056298

Subject(s)
Key words

Anticancer; Cancer metabolism; Pyruvate dehydrogenase kinase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyruvate Dehydrogenase Complex / Protein Serine-Threonine Kinases Language: En Journal: Eur J Med Chem Year: 2024 Document type: Article

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