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Safety and stable survival of stem-cell-derived retinal organoid for 2 years in patients with retinitis pigmentosa.
Hirami, Yasuhiko; Mandai, Michiko; Sugita, Sunao; Maeda, Akiko; Maeda, Tadao; Yamamoto, Midori; Uyama, Hirofumi; Yokota, Satoshi; Fujihara, Masashi; Igeta, Masataka; Daimon, Takashi; Fujita, Kanako; Ito, Tomoko; Shibatani, Naoki; Morinaga, Chikako; Hayama, Tetsuya; Nakamura, Aya; Ueyama, Kazuki; Ono, Keiichi; Ohara, Hidetaka; Fujiwara, Masayo; Yamasaki, Suguru; Watari, Kenji; Bando, Kiyoko; Kawabe, Keigo; Ikeda, Atsushi; Kimura, Toru; Kuwahara, Atsushi; Takahashi, Masayo; Kurimoto, Yasuo.
Affiliation
  • Hirami Y; Department of Ophthalmology, Kobe City Eye Hospital, Kobe 650-0047, Japan; Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe 650-0047, Japan; Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan. Electronic address: yhira
  • Mandai M; Department of Ophthalmology, Kobe City Eye Hospital, Kobe 650-0047, Japan; Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan; Research Center, Kobe City Eye Hospital, Kobe 650-0047, Japan; RIKEN Program for Drug Discovery and Medical Technology
  • Sugita S; Department of Ophthalmology, Kobe City Eye Hospital, Kobe 650-0047, Japan; Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.
  • Maeda A; Department of Ophthalmology, Kobe City Eye Hospital, Kobe 650-0047, Japan; Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan; Research Center, Kobe City Eye Hospital, Kobe 650-0047, Japan.
  • Maeda T; Department of Ophthalmology, Kobe City Eye Hospital, Kobe 650-0047, Japan; Research Center, Kobe City Eye Hospital, Kobe 650-0047, Japan.
  • Yamamoto M; Department of Ophthalmology, Kobe City Eye Hospital, Kobe 650-0047, Japan; Research Center, Kobe City Eye Hospital, Kobe 650-0047, Japan.
  • Uyama H; Department of Ophthalmology, Kobe City Eye Hospital, Kobe 650-0047, Japan; Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe 650-0047, Japan.
  • Yokota S; Department of Ophthalmology, Kobe City Eye Hospital, Kobe 650-0047, Japan; Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe 650-0047, Japan; Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.
  • Fujihara M; Department of Ophthalmology, Kobe City Eye Hospital, Kobe 650-0047, Japan; Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe 650-0047, Japan; Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.
  • Igeta M; Department of Biostatistics, Hyogo Medical University, Nishinomiya 663-8501, Japan.
  • Daimon T; Department of Biostatistics, Hyogo Medical University, Nishinomiya 663-8501, Japan.
  • Fujita K; Research Center, Kobe City Eye Hospital, Kobe 650-0047, Japan.
  • Ito T; Research Center, Kobe City Eye Hospital, Kobe 650-0047, Japan.
  • Shibatani N; Research Center, Kobe City Eye Hospital, Kobe 650-0047, Japan.
  • Morinaga C; RIKEN Program for Drug Discovery and Medical Technology Platforms, Yokohama 230-0045, Japan.
  • Hayama T; Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co. Ltd., Kobe 650-0047, Japan.
  • Nakamura A; Technology Research & Development Division, Sumitomo Pharma Co. Ltd., Kobe 650-0047, Japan.
  • Ueyama K; Technology Research & Development Division, Sumitomo Pharma Co. Ltd., Kobe 650-0047, Japan.
  • Ono K; Technology Research & Development Division, Sumitomo Pharma Co. Ltd., Kobe 650-0047, Japan.
  • Ohara H; Regenerative & Cellular Medicine Office, Sumitomo Pharma Co. Ltd., Tokyo 103-6012, Japan.
  • Fujiwara M; Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co. Ltd., Kobe 650-0047, Japan.
  • Yamasaki S; Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co. Ltd., Kobe 650-0047, Japan.
  • Watari K; Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co. Ltd., Kobe 650-0047, Japan.
  • Bando K; Regenerative & Cellular Medicine Office, Sumitomo Pharma Co. Ltd., Tokyo 103-6012, Japan.
  • Kawabe K; Regenerative & Cellular Medicine Office, Sumitomo Pharma Co. Ltd., Tokyo 103-6012, Japan.
  • Ikeda A; Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co. Ltd., Kobe 650-0047, Japan.
  • Kimura T; Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co. Ltd., Kobe 650-0047, Japan; Regenerative & Cellular Medicine Office, Sumitomo Pharma Co. Ltd., Tokyo 103-6012, Japan.
  • Kuwahara A; Regenerative & Cellular Medicine Kobe Center, Sumitomo Pharma Co. Ltd., Kobe 650-0047, Japan.
  • Takahashi M; Department of Ophthalmology, Kobe City Eye Hospital, Kobe 650-0047, Japan.
  • Kurimoto Y; Department of Ophthalmology, Kobe City Eye Hospital, Kobe 650-0047, Japan; Department of Ophthalmology, Kobe City Medical Center General Hospital, Kobe 650-0047, Japan; Laboratory for Retinal Regeneration, RIKEN Center for Biosystems Dynamics Research, Kobe 650-0047, Japan.
Cell Stem Cell ; 30(12): 1585-1596.e6, 2023 12 07.
Article in En | MEDLINE | ID: mdl-38065067
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinitis Pigmentosa / Induced Pluripotent Stem Cells Limits: Animals / Humans Language: En Journal: Cell Stem Cell Year: 2023 Document type: Article Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinitis Pigmentosa / Induced Pluripotent Stem Cells Limits: Animals / Humans Language: En Journal: Cell Stem Cell Year: 2023 Document type: Article Country of publication: Estados Unidos