Predictors of Detectable Viremia, Outcomes, and Implications for Management of People Living With HIV Who Are Receiving Antiretroviral Therapy in Southern Nigeria.
Open Forum Infect Dis
; 10(12): ofad562, 2023 Dec.
Article
in En
| MEDLINE
| ID: mdl-38088982
ABSTRACT
Background:
This study examined the prevalence and factors associated with detectable viremia, as well as clinical outcomes among people with HIV (PWH) receiving antiretroviral therapy (ART) who initially achieved viral suppression in 2 southern states in Nigeria.Methods:
The retrospective cohort study used data from the electronic medical records of 96 comprehensive ART centers. PWH were followed up who achieved viral suppression (viral load [VL] ≤50â copies/mL) upon starting ART based on the first VL test. We examined the presence of detectable viremia in follow-up VL results, graded by the absolute VL count from the second and third consecutive VL tests as follows transient viremia (second follow-up VL, 51-999â copies/mL; third, ≤50â copies/mL), persistent viremia (second follow-up VL, 51-999â copies/mL or ≥1000â copies/mL; third, >50â copies/mL), and virologic failure (second and third follow-up VL, >1000â copies/mL). We analyzed demographic and clinical factors associated with detectable viremia using logistic regression analysis on Stata 14.Results:
Overall, 15 050 PWH had achieved viral suppression following ART initiation (median age, 34 years; 71.3% female). On follow-up, 3101 (20.6%) had a viremic event 11.6%, transient viremia; 8.8%, persistent viremia; 0.2%, virologic failure. Shorter duration of ART (P < .001), being 0 to 14 years of age (P < .001), and not being enrolled in a differentiated service delivery model (P < .001) were significantly associated with detectable viremia.Conclusions:
Our study shows that people who initially attain vial suppression upon starting ART remain at risk of detectable viremia.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Open Forum Infect Dis
Year:
2023
Document type:
Article
Affiliation country:
Nigeria