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Native and Ion Mobility Mass Spectrometry Characterization of Alpha 1 Antitrypsin Variants and Oligomers.
Vickers, Sarah; Irving, James; Lomas, David A; Thalassinos, Konstantinos.
Affiliation
  • Vickers S; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK.
  • Irving J; Institute of Structural and Molecular Biology, Birkbeck College, University of London, London, UK.
  • Lomas DA; Institute of Structural and Molecular Biology, Birkbeck College, University of London, London, UK.
  • Thalassinos K; UCL Respiratory, University College London, London, UK.
Methods Mol Biol ; 2750: 41-55, 2024.
Article in En | MEDLINE | ID: mdl-38108966
ABSTRACT
In this chapter, we describe a method for analyzing both recombinant and plasma-derived alpha 1 antitrypsin and its oligomers by means of native ion mobility mass spectrometry. Our experimental workflow can be applied to other variants of alpha 1 antitrypsin and its oligomers as well as being used to probe their interactions with small molecules in the gas phase.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alpha 1-Antitrypsin / Ion Mobility Spectrometry Language: En Journal: Methods Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2024 Document type: Article Affiliation country: Reino Unido Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Alpha 1-Antitrypsin / Ion Mobility Spectrometry Language: En Journal: Methods Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2024 Document type: Article Affiliation country: Reino Unido Country of publication: Estados Unidos