Anemia and Optimal Transfusion Thresholds in Brain-Injured Patients: A Narrative Review of the Literature.
Anesth Analg
; 138(5): 992-1002, 2024 May 01.
Article
in En
| MEDLINE
| ID: mdl-38109853
ABSTRACT
Anemia is a highly prevalent condition that may compromise oxygen delivery to vital organs, especially among the critically ill. Although current evidence supports the adoption of a restrictive transfusion strategy and threshold among the nonbleeding critically ill patient, it remains unclear whether this practice should apply to the brain-injured patient, given the predisposition to cerebral ischemia in this patient population, in which even nonprofound anemia may exert a detrimental effect on clinical outcomes. The purpose of this review is to provide an overview of the pathophysiological changes related to impaired cerebral oxygenation in the brain-injured patient and to present the available evidence on the effect of anemia and varying transfusion thresholds on the clinical outcomes of patients with acute brain injury.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Critical Illness
/
Anemia
Limits:
Humans
Language:
En
Journal:
Anesth Analg
Year:
2024
Document type:
Article
Affiliation country:
Canadá
Country of publication:
Estados Unidos