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Analysis across Taiwan Biobank, Biobank Japan, and UK Biobank identifies hundreds of novel loci for 36 quantitative traits.
Chen, Chia-Yen; Chen, Tzu-Ting; Feng, Yen-Chen Anne; Yu, Mingrui; Lin, Shu-Chin; Longchamps, Ryan J; Wang, Shi-Heng; Hsu, Yi-Hsiang; Yang, Hwai-I; Kuo, Po-Hsiu; Daly, Mark J; Chen, Wei J; Huang, Hailiang; Ge, Tian; Lin, Yen-Feng.
Affiliation
  • Chen CY; Biogen, Cambridge, MA 02142, USA; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT
  • Chen TT; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli 35053, Taiwan.
  • Feng YA; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142,
  • Yu M; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Lin SC; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli 35053, Taiwan.
  • Longchamps RJ; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Wang SH; National Center for Geriatrics and Welfare Research, National Health Research Institutes, Miaoli 35053, Taiwan; Department of Public Health, College of Public Health, China Medical University, Taichung 40678, Taiwan.
  • Hsu YH; Marcus Institute for Aging Research and Harvard Medical School, Boston, MA 02131, USA; Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Harvard School of Public Health, Boston, MA 02115, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Yang HI; Genomics Research Center, Academia Sinica, Taipei 115201, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei 112304, Taiwan; Doctoral Program of Clinical and Experimental Medicine, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan; Biomedical Translation Research Ce
  • Kuo PH; Department of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 100025, Taiwan; Department of Psychiatry, College of Medicine and National Taiwan University Hospital, Taipei 106319, Taiwan.
  • Daly MJ; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute for Molecular Medicine Finland FIMM, University of Helsinki, 00014 Helsinki, Finland.
  • Chen WJ; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli 35053, Taiwan; Department of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei 100025, Taiwan; Department of Psychiatry, College of Medi
  • Huang H; Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA 02114, USA. Electronic address: hhuang@at
  • Ge T; Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Boston, MA 02114, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA
  • Lin YF; Center for Neuropsychiatric Research, National Health Research Institutes, Miaoli 35053, Taiwan; Department of Public Health & Medical Humanities, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112304, Taiwan; Institute of Behavioral Medicine, College of Medicine, National
Cell Genom ; 3(12): 100436, 2023 12 13.
Article in En | MEDLINE | ID: mdl-38116116
ABSTRACT
Genome-wide association studies (GWASs) have identified tens of thousands of genetic loci associated with human complex traits. However, the majority of GWASs were conducted in individuals of European ancestries. Failure to capture global genetic diversity has limited genomic discovery and has impeded equitable delivery of genomic knowledge to diverse populations. Here we report findings from 102,900 individuals across 36 human quantitative traits in the Taiwan Biobank (TWB), a major biobank effort that broadens the population diversity of genetic studies in East Asia. We identified 968 novel genetic loci, pinpointed novel causal variants through statistical fine-mapping, compared the genetic architecture across TWB, Biobank Japan, and UK Biobank, and evaluated the utility of cross-phenotype, cross-population polygenic risk scores in disease risk prediction. These results demonstrated the potential to advance discovery through diversifying GWAS populations and provided insights into the common genetic basis of human complex traits in East Asia.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cell Genom / Cell genomics Year: 2023 Document type: Article Country of publication: Estados Unidos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Cell Genom / Cell genomics Year: 2023 Document type: Article Country of publication: Estados Unidos