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Cardiac valvular involvement in granulomatosis with polyangiitis in long-term observation.
Borowiec, Anna; Rosinska, Magdalena; Kowalik, Ilona; Rybski, Sebastian; Chwyczko, Tomasz; Jankowski, Jan; Zycinska, Katarzyna.
Affiliation
  • Borowiec A; Medical University of Warsaw, Warsaw, Poland; National Institute of Oncology, Warsaw, Poland. Electronic address: ania_borowiec@yahoo.com.
  • Rosinska M; National Institute of Oncology, Warsaw, Poland.
  • Kowalik I; National Institute of Cardiology, Warsaw, Poland.
  • Rybski S; National Institute of Oncology, Warsaw, Poland.
  • Chwyczko T; National Institute of Cardiology, Warsaw, Poland.
  • Jankowski J; Medical University of Warsaw, Warsaw, Poland.
  • Zycinska K; Medical University of Warsaw, Warsaw, Poland; Central Clinical Hospital of Ministry of MSWiA, Warsaw, Poland.
Rev Port Cardiol ; 43(3): 97-103, 2024 Mar.
Article in En, Pt | MEDLINE | ID: mdl-38122897
ABSTRACT
INTRODUCTION AND

OBJECTIVES:

Granulomatosis with polyangiitis (GPA) is an antineutrophil cytoplasmic autoantibody (ANCA)-associated systemic vasculitis and is characterized by inflammation of blood vessels. The aim of the present study was to assess cardiac valvular changes in patients with GPA in a cohort of 105 patients followed for a mean of six years.

METHODS:

We followed 105 patients (mean age 50.4 years, 67 female) for a mean of 6.2±1.3 years. Echocardiography and laboratory tests were performed in all patients.

RESULTS:

At baseline, 43% of patients were diagnosed with aortic regurgitation (AR), which was the most common valvular lesion. Moreover, it was the only valvular involvement that significantly increased during observation (p=0.01). In a multivariate model, only D-dimer level was a predictor of AR in this group of patients (OR 8.0 (95% CI 1.7-38.2, p=0.01).

CONCLUSIONS:

Involvement of the heart valves is a common finding in patients with GPA, but significant valvular disease is a rare complication. The most common valvular disease in this group of patients is AR. Aortic valves are also the most prone to degeneration in the course of the vasculitis.
Subject(s)
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Granulomatosis with Polyangiitis / Heart Valve Diseases Limits: Female / Humans / Middle aged Language: En / Pt Journal: Rev Port Cardiol Journal subject: CARDIOLOGIA Year: 2024 Document type: Article

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Granulomatosis with Polyangiitis / Heart Valve Diseases Limits: Female / Humans / Middle aged Language: En / Pt Journal: Rev Port Cardiol Journal subject: CARDIOLOGIA Year: 2024 Document type: Article