Gene of the month: VSTM2A.
J Clin Pathol
; 77(2): 73-76, 2024 Jan 18.
Article
in En
| MEDLINE
| ID: mdl-38124011
ABSTRACT
The V-set and transmembrane domain containing 2A (VSTM2A) gene is located on chromosome 7. In the physiological state, VSTM2A regulates preadipocyte cell differentiation. VSTM2A is highly expressed in normal human brain tissue and minimally expressed in other normal tissues. Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney is a distinct renal tumour subtype with signature chromosomal copy number alterations and an indolent outcome in the majority of cases. VSTM2A overexpression is highly enriched in this renal cancer subtype and has been shown to have potential diagnostic value in distinguishing MTSCC from renal tumours with overlapping histological appearances.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Carcinoma, Renal Cell
/
Adenocarcinoma, Mucinous
/
Kidney Neoplasms
Limits:
Humans
Language:
En
Journal:
J Clin Pathol
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos