Left atrial strain in patients after arterial switch operation for transposition of the great arteries.
Acta Cardiol
; 79(6): 672-678, 2024 Aug.
Article
in En
| MEDLINE
| ID: mdl-38126324
ABSTRACT
BACKGROUND:
Left atrial (LA) strain, comprising LA reservoir, conduit and contractile function could add mechanistic information of patients after arterial switch operation (ASO) for transposition of the great arteries (TGA). ASO patients might have abnormal ventriculoarterial coupling, which makes them vulnerable to left ventricle (LV) dysfunction and results in reduced exercise capacity. This explorative study aimed to evaluate the relation between LA strain, atrial size, ventricular function, and exercise data obtained by cardiopulmonary exercise testing (CPET).METHODS:
In a cohort of 44 patients (71% male, mean age 25 ± 4 years) LA strain was measured using transthoracic speckle-tracking echocardiography. Further assessment involved standard echocardiography, CPET evaluation, and blood sampling. LA strain values were compared to normal values. Correlations were calculated. Regression analysis with all strain variables to the CPET data was performed.RESULTS:
LA reservoir, conduit and contractile strain were normal in 30%, 89% and 50% of the patients, respectively. LA reservoir/contractile strain correlated to LV ejection fraction (ρ 0.310/-0.159, respectively) and LA reservoir/conduit strain correlated to the LA volume index (ρ 0.336/-0.357, respectively). None of the individual LA strain parameters were associated with the CPET variables. In multivariate regression analysis, LA contractile strain was significantly associated with the percentage of predicted maximal heart rate (ß - 2.555).CONCLUSIONS:
These data suggest that in TGA patients after ASO repair LA strain is impaired and correlates with LA size and LV function. However, impaired LA strain wasn't associated with the standard CPET parameters. As such, clinical significance needs to be further unravelled.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transposition of Great Vessels
/
Atrial Function, Left
/
Arterial Switch Operation
/
Heart Atria
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Acta Cardiol
Year:
2024
Document type:
Article
Affiliation country:
Bélgica
Country of publication:
Reino Unido