Ligand-Enabled Palladium(II)-Catalyzed γ-C(sp3)-H Arylation of Primary Aliphatic Amines.
Org Lett
; 26(1): 29-34, 2024 Jan 12.
Article
in En
| MEDLINE
| ID: mdl-38127514
ABSTRACT
The Pd(II)/sulfoxide-2-hydroxypyridine catalytic system shows promising activity in C-H activation chemistry. In this study, we showcase how this catalytic system solves the problem of native primary amine-directed γ-C(sp3)-H arylation. Primary amines with different complexities are compatible with the established methodology, and the range of applicable substrates can be expanded to include pyridine, oxime ether, and pyridine N-oxide.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2024
Document type:
Article
Affiliation country:
China