Cancer-related fatigue trajectories up to 5 years after curative treatment for oesophageal cancer.
Br J Cancer
; 130(4): 628-637, 2024 03.
Article
in En
| MEDLINE
| ID: mdl-38135716
ABSTRACT
BACKGROUND:
Whether cancer-related fatigue develops differently after curative-intended oesophageal cancer treatment and the related modifiable factors are unclear.METHODS:
This population-based and longitudinal cohort included 409 oesophageal cancer patients who underwent curative oesophagectomy in 2013-2020 in Sweden. The main outcome was cancer-related fatigue trajectories with measurements at 1, 1.5, 2, 2.5, 3, 4 and 5 years postoperatively by validated EORTC QLQ-FA12 questionnaire, and analysed using growth mixture models. Weighted logistic regressions provided odds ratios (OR) with 95% confidence intervals (95% CI) for underlying sociodemographic, clinical, and patient-reported outcome factors in relation to the identified trajectories.RESULTS:
Two distinct overall cancer-related fatigue trajectories were identified low level of persistent fatigue and high level of increasing fatigue, with 64% and 36% of patients, respectively. The odds of having high level of fatigue trajectory were increased by Charlson comorbidity index (≥ 2 versus 0 OR = 2.52, 95% CI 1.07-5.94), pathological tumour Stage (III-IV versus 0-I OR = 2.52, 95% CI 1.33-4.77), anxiety (OR = 7.58, 95% CI 2.20-26.17), depression (OR = 15.90, 95% CI 4.44-56.93) and pain (continuous score OR = 1.02, 95% CI 1.01-1.04).CONCLUSIONS:
Long-term trajectories with high level of increasing cancer-related fatigue and the associated modifiable factors were identified after oesophageal cancer treatment. The results may facilitate early identification and targeted intervention for such high-risk patients.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Esophageal Neoplasms
Limits:
Humans
Country/Region as subject:
Europa
Language:
En
Journal:
Br J Cancer
Year:
2024
Document type:
Article
Affiliation country:
Suecia