Differential postnatal development of mu-, delta- and kappa-opioid binding sites in rat brain.
Brain Res
; 428(1): 53-8, 1987 Jan.
Article
in En
| MEDLINE
| ID: mdl-3815117
ABSTRACT
With selective labelling techniques and analysis of saturation curves it is shown that in rat brain the concentrations of mu-, delta- and kappa-binding sites increase differentially during postnatal development. There are no changes in the binding affinities. The concentration (pmol/g brain) of kappa-sites are first to reach adult levels, namely between 7 and 14 days after birth. Adult levels of mu-sites are attained between 14 and 21 days after birth. The most striking finding is that development of delta-sites, which are not detectable 3 days after birth by the method used, lags markedly behind that of mu- and kappa-sites. The profile of development in rat brain is compared to that found previously in mouse brain.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain
/
Endorphins
/
Animals, Newborn
Limits:
Animals
Language:
En
Journal:
Brain Res
Year:
1987
Document type:
Article