Macrophage polarization and signaling in diabetic kidney disease: a catalyst for disease progression.
Am J Physiol Renal Physiol
; 326(3): F301-F312, 2024 Mar 01.
Article
in En
| MEDLINE
| ID: mdl-38153850
ABSTRACT
Diabetic kidney disease (DKD) is a serious complication of diabetes affecting millions of people worldwide. Macrophages, a critical immune cell type, are central players in the development and progression of DKD. In this comprehensive review, we delve into the intricate role of macrophages in DKD, examining how they can become polarized into proinflammatory M1 or anti-inflammatory M2 phenotypes. We explore the signaling pathways involved in macrophage recruitment and polarization in the kidneys, including the key cytokines and transcription factors that promote M1 and M2 polarization. In addition, we discuss the latest clinical studies investigating macrophages in DKD and explore the potential of hypoglycemic drugs for modulating macrophage polarization. By gaining a deeper understanding of the mechanisms that regulate macrophage polarization in DKD, we may identify novel therapeutic targets for this debilitating complication of diabetes. This review provides valuable insights into the complex interplay between macrophages and DKD, shedding light on the latest developments in this important area of research. This review aims to enhance understanding of the role that macrophages play in the pathogenesis of DKD.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Diabetes Mellitus
/
Diabetic Nephropathies
Limits:
Humans
Language:
En
Journal:
Am J Physiol Renal Physiol
/
Am. j. physiol., Renal fluid electrolyte physiol
/
American journal of physiology. Renal, fluid and electrolyte physiology
Journal subject:
FISIOLOGIA
/
NEFROLOGIA
Year:
2024
Document type:
Article
Affiliation country:
Líbano
Country of publication:
Estados Unidos