Pediatric systemic juvenile idiopathic arthritis-related lung disease: Description of clinical cohort and review of management.
Pediatr Pulmonol
; 59(3): 724-733, 2024 Mar.
Article
in En
| MEDLINE
| ID: mdl-38155594
ABSTRACT
CONTEXT Since the early 2010s, there has been an increased awareness of interstitial lung disease in systemic juvenile idiopathic arthritis (sJIA-LD) in pediatric patients. Despite the increase in prevalence of sJIA-LD, little is known about this disease process and effective therapeutic management. OBJECTIVES:
To identify and characterize the disease process and management of interstitial lung disease related to systemic juvenile idiopathic arthritis. STUDYDESIGN:
In this single-center, retrospective case series of 9 patients, we analyze demographic, clinical, radiographic, and laboratory data to corroborate common clinical characteristics and describe an approach for diagnosis and monitoring of sJIA-LD. DATA EXTRACTION All data was extracted through electronic medical records and individually reviewed by two pediatric pulmonologists and two pediatric rheumatologists.RESULTS:
Our results were similar to other described cases of sJIA-LD as patients in our cohort were more likely to be younger, have a history of macrophage activation syndrome and prior use of biologic therapies. In contrast to prior studies, they did not present with peripheral lymphadenopathy and hepatosplenomegaly.LIMITATIONS:
The cohort size was small and data is reflective of one center's approach to management of a rare lung disease process.CONCLUSION:
Interstitial lung disease due to sJIA is rare and management can be difficult in these complex patients.More research is necessary to understand the increased incidence and treatment of sJIA-LD in pediatric population.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Arthritis, Juvenile
/
Lung Diseases, Interstitial
/
Macrophage Activation Syndrome
Limits:
Child
/
Humans
Language:
En
Journal:
Pediatr Pulmonol
Journal subject:
PEDIATRIA
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos