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PDGF-AA loaded photo-crosslinked chitosan-based hydrogel for promoting wound healing.
Cai, Zhuangzhuang; Mo, Zhendong; Zhou, Qing; Zhou, Xujie; Huang, Feng; Jiang, Jiaqi; Li, Hang; Tang, Shunqing.
Affiliation
  • Cai Z; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
  • Mo Z; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
  • Zhou Q; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
  • Zhou X; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
  • Huang F; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
  • Jiang J; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China.
  • Li H; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China. Electronic address: hangli@jnu.edu.cn.
  • Tang S; Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Department of Biomedical Engineering, Jinan University, Guangzhou 510632, China. Electronic address: tshunqt@jnu.edu.cn.
Int J Biol Macromol ; 258(Pt 2): 129091, 2024 Feb.
Article in En | MEDLINE | ID: mdl-38161023
ABSTRACT
Chitosan-based hydrogels are considered to be ideal materials for promoting wound healing due to their nontoxic, biodegradable, and biocompatible properties. However, the weak mechanical strength, hemostatic properties, and adhesive properties of chitosan hydrogels limit their potential applications. In this study, we synthesized methacrylimide-chitosan (MAC)-4-arm polyethylene glycol (PEG)-dopamine (DMA) (MAC-PEG-DMA) hybrid hydrogels containing A-chain homodimers of platelet-derived growth factor (PDGF-AA) through one-pot photo-crosslinking. The resulting hydrogel exhibited improved mechanical strength and hemostatic properties as demonstrated by both in vitro blood clotting assay and rat liver hemorrhage assay. Furthermore, The PDGF-AA loaded hydrogel was also able to accelerate cell migration and proliferation. Data from skin wounds treated with this hybrid hydrogel showed faster wound closure and collagen maturation. Therefore, MAC-PEG-DMA (PDGF-AA) has great potential as a dressing to promote wound healing.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Hemostatics / Chitosan / Methacrylates Limits: Animals Language: En Journal: Int J Biol Macromol / Int. j. biol. macromol / International journal of biological macromolecules Year: 2024 Document type: Article Affiliation country: China Country of publication: Países Bajos
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Hemostatics / Chitosan / Methacrylates Limits: Animals Language: En Journal: Int J Biol Macromol / Int. j. biol. macromol / International journal of biological macromolecules Year: 2024 Document type: Article Affiliation country: China Country of publication: Países Bajos