Persistence of dengue genome in a remotely infected patient.
Asian Biomed (Res Rev News)
; 17(6): 287-290, 2023 Dec.
Article
in En
| MEDLINE
| ID: mdl-38161351
ABSTRACT
Background:
Dengue virus infection is an intriguing illness. It is traditionally thought of as a self-limited and nonpersistent disease.Objectives:
We report a case with persistent dengue virus genome detectable in hematopoietic cells of a person with remote infection.Methods:
A patient with multiple myeloma in remission was prepared for peripheral blood stem cell (PBSC) transplantation. Plasma and G-CSF-stimulated, mobilized PBSCs were collected. Dengue-specific reverse transcription polymerase chain reaction (RT-PCR) was performed in both pre- and post-stimulated blood specimens. Anti-dengue antibodies by ELISA and by neutralization assay were measured before and after the stem cell mobilization.Results:
The viral genome was detected only in the PBSC of the post-G-CSF-stimulated specimens. Anti-dengue antibodies were negative and positive, by ELISA and neutralization assays, respectively, both before and after stem cell mobilization.Conclusion:
Our findings reveal a persistent infection. Whether and how this strain may interact with subsequent serotype(s) remains to be elucidated.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Asian Biomed (Res Rev News)
Year:
2023
Document type:
Article
Affiliation country:
Tailandia
Country of publication:
Tailandia