Zinc deficiency enhances sensitivity to influenza A associated bacterial pneumonia in mice.
Physiol Rep
; 12(1): e15902, 2024 Jan.
Article
in En
| MEDLINE
| ID: mdl-38163670
ABSTRACT
Although zinc deficiency (secondary to malnutrition) has long been considered an important contributor to morbidity and mortality of infectious disease (e.g. diarrhea disorders), epidemiologic data (including randomized controlled trials with supplemental zinc) for such a role in lower respiratory tract infection are somewhat ambiguous. In the current study, we provide the first preclinical evidence demonstrating that although diet-induced acute zinc deficiency (Zn-D ~50% decrease) did not worsen infection induced by either influenza A (H1N1) or methicillin-resistant staph aureus (MRSA), Zn-D mice were sensitive to the injurious effects of superinfection of H1N1 with MRSA. Although the mechanism underlying the sensitivity of ZnD mice to combined H1N1/MRSA infection is unclear, it was noteworthy that this combination exacerbated lung injury as shown by lung epithelial injury markers (increased BAL protein) and decreased genes related to epithelial integrity in Zn-D mice (surfactant protein C and secretoglobins family 1A member 1). As bacterial pneumonia accounts for 25%-50% of morbidity and mortality from influenza A infection, zinc deficiency may be an important pathology component of respiratory tract infections.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pneumonia, Bacterial
/
Malnutrition
/
Influenza A Virus, H1N1 Subtype
/
Methicillin-Resistant Staphylococcus aureus
Type of study:
Diagnostic_studies
/
Risk_factors_studies
Aspects:
Determinantes_sociais_saude
Limits:
Animals
Language:
En
Journal:
Physiol Rep
Year:
2024
Document type:
Article
Affiliation country:
Estados Unidos