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Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus.
Phelps, Gregory A; Cheramie, Martin N; Fernando, Dinesh M; Selchow, Petra; Meyer, Christopher J; Waidyarachchi, Samanthi L; Dharuman, Suresh; Liu, Jiuyu; Meuli, Michael; Molin, Michael Dal; Killam, Benjamin Y; Murphy, Patricia A; Reeve, Stephanie M; Wilt, Laura A; Anderson, Shelby M; Yang, Lei; Lee, Robin B; Temrikar, Zaid H; Lukka, Pradeep B; Meibohm, Bernd; Polikanov, Yury S; Hobbie, Sven N; Böttger, Erik C; Sander, Peter; Lee, Richard E.
Affiliation
  • Phelps GA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Cheramie MN; Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38103.
  • Fernando DM; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Selchow P; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Meyer CJ; Institute of Medical Microbiology, University of Zurich, Zurich CH-8006, Switzerland.
  • Waidyarachchi SL; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Dharuman S; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Liu J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Meuli M; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Molin MD; Institute of Medical Microbiology, University of Zurich, Zurich CH-8006, Switzerland.
  • Killam BY; National Reference Center for Mycobacteria, Zurich CH-8006, Switzerland.
  • Murphy PA; Institute of Medical Microbiology, University of Zurich, Zurich CH-8006, Switzerland.
  • Reeve SM; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607.
  • Wilt LA; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Anderson SM; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Yang L; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Lee RB; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Temrikar ZH; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Lukka PB; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105.
  • Meibohm B; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163.
  • Polikanov YS; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163.
  • Hobbie SN; Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, TN 38163.
  • Böttger EC; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607.
  • Sander P; Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60607.
  • Lee RE; Center for Biomolecular Sciences, University of Illinois at Chicago, Chicago, IL 60607.
Proc Natl Acad Sci U S A ; 121(2): e2314101120, 2024 Jan 09.
Article in En | MEDLINE | ID: mdl-38165935
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mycobacterium abscessus / Anti-Infective Agents / Mycobacterium Infections, Nontuberculous Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2024 Document type: Article Country of publication: Estados Unidos
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mycobacterium abscessus / Anti-Infective Agents / Mycobacterium Infections, Nontuberculous Limits: Animals / Humans Language: En Journal: Proc Natl Acad Sci U S A Year: 2024 Document type: Article Country of publication: Estados Unidos