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Glycoprotein 2 as a gut gate keeper for mucosal equilibrium between inflammation and immunity.
Zhang, Zhongwei; Tanaka, Izumi; Nakahashi-Ouchida, Rika; Ernst, Peter B; Kiyono, Hiroshi; Kurashima, Yosuke.
Affiliation
  • Zhang Z; Department of Innovative Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
  • Tanaka I; Chiba University Futuristic Mucosal Vaccine Research and Development Synergy Institute (cSIMVa), Chiba, Japan.
  • Nakahashi-Ouchida R; Department of Innovative Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan.
  • Ernst PB; Chiba University Futuristic Mucosal Vaccine Research and Development Synergy Institute (cSIMVa), Chiba, Japan.
  • Kiyono H; Chiba University Futuristic Mucosal Vaccine Research and Development Synergy Institute (cSIMVa), Chiba, Japan.
  • Kurashima Y; Division of Mucosal Immunology, IMSUT Distinguished Professor Unit, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
Semin Immunopathol ; 45(4-6): 493-507, 2024 Jan.
Article in En | MEDLINE | ID: mdl-38170255
ABSTRACT
Glycoprotein 2 (GP2) is a widely distributed protein in the digestive tract, contributing to mucosal barrier maintenance, immune homeostasis, and antigen-specific immune response, while also being linked to inflammatory bowel disease (IBD) pathogenesis. This review sheds light on the extensive distribution of GP2 within the gastrointestinal tract and its intricate interplay with the immune system. Furthermore, the significance of GP2 autoantibodies in diagnosing and categorizing IBD is underscored, alongside the promising therapeutic avenues for modulating GP2 to regulate immunity and maintain mucosal balance.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammatory Bowel Diseases / GPI-Linked Proteins / Intestinal Mucosa Limits: Animals / Humans Language: En Journal: Semin Immunopathol Journal subject: ALERGIA E IMUNOLOGIA / PATOLOGIA Year: 2024 Document type: Article Affiliation country: Japón Country of publication: Alemania
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Inflammatory Bowel Diseases / GPI-Linked Proteins / Intestinal Mucosa Limits: Animals / Humans Language: En Journal: Semin Immunopathol Journal subject: ALERGIA E IMUNOLOGIA / PATOLOGIA Year: 2024 Document type: Article Affiliation country: Japón Country of publication: Alemania